Mdm2 information

MDM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RV1, 1T4E, 1T4F, 1YCR, 1Z1M, 2AXI, 2C6A, 2C6B, 2FOP, 2GV2, 2HDP, 2LZG, 2M86, 2MPS, 2RUH, 2VJE, 2VJF, 3EQS, 3G03, 3IUX, 3IWY, 3JZK, 3JZR, 3JZS, 3LBK, 3LBL, 3LNJ, 3LNZ, 3MQS, 3TJ2, 3TPX, 3TU1, 3V3B, 3VBG, 3VZV, 3W69, 4DIJ, 4ERE, 4ERF, 4HBM, 4HFZ, 4HG7, 4JV7, 4JV9, 4JVE, 4JVR, 4JWR, 4MDN, 4MDQ, 4OAS, 4OBA, 4OCC, 4ODE, 4ODF, 4OGN, 4OGT, 4OGV, 4OQ3, 4QO4, 4QOC, 4UMN, 4WT2, 4XXB, 4ZYC, 4ZYF, 4ZYI, 4UE1, 4UD7, 5AFG, 5HMI, 5HMK, 5HMH, 5C5A
Identifiers
Aliases	MDM2, ACTFS, HDMX, hdm2, MDM2 proto-oncogene, LSKB
External IDs	OMIM: 164785; MGI: 96952; HomoloGene: 1793; GeneCards: MDM2; OMA:MDM2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	68,845,544 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	117,546,663 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ventricular zone; ; right uterine tube; ; olfactory zone of nasal mucosa; ; sural nerve; ; epithelium of colon; ; epithelium of nasopharynx; ; stromal cell of endometrium; ; right lobe of liver; ; ganglionic eminence;
	Top expressed in
	zygote; ; gastrula; ; seminiferous tubule; ; spermatocyte; ; granulocyte; ; spermatid; ; aortic valve; ; secondary oocyte; ; ascending aorta; ; muscle of thigh;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	scaffold protein binding; protein binding; enzyme binding; metal ion binding; identical protein binding; ubiquitin protein ligase binding; p53 binding; SUMO transferase activity; ubiquitin-protein transferase activity; transferase activity; ligase activity; 5S rRNA binding; zinc ion binding; ribonucleoprotein complex binding; protein N-terminus binding; ubiquitin protein ligase activity; NEDD8 ligase activity; disordered domain specific binding; protein domain specific binding; receptor serine/threonine kinase binding; peroxisome proliferator activated receptor binding; ubiquitin binding;
Cellular component	cytosol; endocytic vesicle membrane; plasma membrane; synapse; nuclear body; cytoplasm; nucleus; nucleoplasm; nucleolus; protein-containing complex;
Biological process	negative regulation of signal transduction by p53 class mediator; endocardial cushion morphogenesis; cellular response to UV-C; atrial septum development; regulation of heart rate; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of gene expression; blood vessel development; positive regulation of cell population proliferation; negative regulation of DNA damage response, signal transduction by p53 class mediator; response to ether; blood vessel remodeling; cellular response to hypoxia; heart valve development; cellular response to estrogen stimulus; negative regulation of apoptotic process; cellular response to organic substance; cellular response to hydrogen peroxide; response to cocaine; cardiac septum morphogenesis; negative regulation of transcription by RNA polymerase II; peptidyl-lysine modification; positive regulation of cell cycle; ventricular septum development; positive regulation of protein export from nucleus; response to steroid hormone; cellular response to growth factor stimulus; regulation of protein catabolic process; cellular response to antibiotic; negative regulation of gene expression; positive regulation of mitotic cell cycle; heart development; cellular response to alkaloid; cellular response to vitamin B1; response to magnesium ion; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; cellular response to peptide hormone stimulus; cellular response to organic cyclic compound; viral process; response to iron ion; regulation of gene expression; response to antibiotic; traversing start control point of mitotic cell cycle; protein ubiquitination; negative regulation of protein processing; establishment of protein localization; response to toxic substance; response to morphine; atrioventricular valve morphogenesis; protein localization to nucleus; regulation of signal transduction by p53 class mediator; positive regulation of vascular associated smooth muscle cell proliferation; response to water-immersion restraint stress; negative regulation of neuron projection development; positive regulation of vascular associated smooth muscle cell migration; protein deubiquitination; protein sumoylation; transcription factor catabolic process; protein autoubiquitination; response to formaldehyde; protein destabilization; negative regulation of transcription, DNA-templated; proteolysis involved in cellular protein catabolic process; cellular response to gamma radiation; cellular response to actinomycin D; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; amyloid fibril formation; protein-containing complex assembly; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4193
	17246
	ENSG00000135679
	ENSMUSG00000020184
	Q00987
	P23804
NM_001145336; NM_001145337; NM_001145339; NM_001145340; NM_001278462;
	NM_002392; NM_006878; NM_006879; NM_006880; NM_006881; NM_006882; NM_032739; NM_001367990
	NM_001288586; NM_010786
NP_001138809; NP_001138811; NP_001138812; NP_001265391; NP_002383;
	NP_001354919
	NP_001275515; NP_034916
	Wikidata
View/Edit Human	View/Edit Mouse

Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene.^[5]^[6] Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and as an inhibitor of p53 transcriptional activation.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135679 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020184 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B (July 1992). "Amplification of a gene encoding a p53-associated protein in human sarcomas". Nature. 358 (6381): 80–3. Bibcode:1992Natur.358...80O. doi:10.1038/358080a0. hdl:2027.42/62637. PMID 1614537. S2CID 1056405.
^ Wade M, Wong ET, Tang M, Stommel JM, Wahl GM (November 2006). "Hdmx modulates the outcome of p53 activation in human tumor cells". The Journal of Biological Chemistry. 281 (44): 33036–44. doi:10.1074/jbc.M605405200. PMID 16905769. S2CID 16619596.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135679 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020184 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1614537-5] Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B (July 1992). "Amplification of a gene encoding a p53-associated protein in human sarcomas". Nature. 358 (6381): 80–3. Bibcode:1992Natur.358...80O. doi:10.1038/358080a0. hdl:2027.42/62637. PMID 1614537. S2CID 1056405.

[pmid16905769-6] Wade M, Wong ET, Tang M, Stommel JM, Wahl GM (November 2006). "Hdmx modulates the outcome of p53 activation in human tumor cells". The Journal of Biological Chemistry. 281 (44): 33036–44. doi:10.1074/jbc.M605405200. PMID 16905769. S2CID 16619596.

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