negative regulation of proteasomal ubiquitin-dependent protein catabolic process
apoptotic signaling pathway
protein desumoylation
activation of cysteine-type endopeptidase activity involved in apoptotic process
protein sumoylation
positive regulation of transcription by RNA polymerase II
proteolysis
regulation of definitive erythrocyte differentiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
29843
223870
Ensembl
ENSG00000079387
ENSMUSG00000033075
UniProt
Q9P0U3
P59110
RefSeq (mRNA)
NM_001267594 NM_001267595 NM_014554
NM_144851 NM_001379573
RefSeq (protein)
NP_001254523 NP_001254524
NP_659100 NP_001366502
Location (UCSC)
Chr 12: 48.04 – 48.11 Mb
Chr 15: 97.94 – 97.99 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Sentrin-specific protease 1 is an enzyme that in humans is encoded by the SENP1 gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000079387 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000033075 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gong L, Millas S, Maul GG, Yeh ET (Feb 2000). "Differential regulation of sentrinized proteins by a novel sentrin-specific protease". The Journal of Biological Chemistry. 275 (5): 3355–9. doi:10.1074/jbc.275.5.3355. PMID 10652325.
^Bailey D, O'Hare P (Jan 2004). "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1". The Journal of Biological Chemistry. 279 (1): 692–703. doi:10.1074/jbc.M306195200. PMID 14563852.
^"Entrez Gene: SENP1 SUMO1/sentrin specific peptidase 1".
that in humans is encoded by the SENP1 gene. So far there are six SUMO proteases in humans that have been designated SENP1-3 and SENP5-7 (sentrin/SUMO-specific...
recently been correlated with increased expression of the genes ANP32D and SENP1. CMS is characterised by polycythaemia (with subsequent increased haematocrit)...
interact with: ASK1, Collagen, type I, alpha 1, Glucocorticoid receptor, SENP1, TXNIP. NF-κB – by reducing a disulfide bond in NF-κB, Trx1 promotes binding...
structure of human SENP1 mutant (C603S) in complex with SUMO-1 2io2: Crystal structure of human Senp2 in complex with RanGAP1-SUMO-1 2iy0: SENP1 (MUTANT) SUMO1...
of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2) 2ckh: SENP1-SUMO2 COMPLEX 2d07: Crystal Structure of SUMO-3-modified Thymine-DNA Glycosylase...
of human Senp2 in complex with RanGAP1-SUMO-1 2io3: Crystal structure of human Senp2 in complex with RanGAP1-SUMO-2 2iy0: SENP1 (MUTANT) SUMO1 RANGAP...
J, et al. (2005). "Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a...
the localization and proteolytic activity of the SUMO-specific protease, SENP1". The Journal of Biological Chemistry. 279 (1): 692–703. doi:10.1074/jbc...