Gray platelet syndrome is inherited in an autosomal recessive manner.
Specialty
Hematology
Gray platelet syndrome (GPS), or platelet alpha-granule deficiency,[1] is a rare congenital autosomal recessive bleeding disorder caused by a reduction or absence of alpha-granules in blood platelets, and the release of proteins normally contained in these granules into the marrow, causing myelofibrosis.[2] The name derives from the initial observation of gray appearance of platelets with a paucity of granules on blood films from a patient with a lifelong bleeding disorder.[3]
^Online Mendelian Inheritance in Man (OMIM): 139090
^Nurden AT, Nurden P (January 2007). "The gray platelet syndrome: clinical spectrum of the disease". Blood Reviews. 21 (1): 21–36. doi:10.1016/j.blre.2005.12.003. PMID 16442192.
Grayplateletsyndrome (GPS), or platelet alpha-granule deficiency, is a rare congenital autosomal recessive bleeding disorder caused by a reduction or...
disorder occurs for inherited diseases like Bernard–Soulier syndrome, grayplateletsyndrome and May–Hegglin anomaly. Symptoms usually present from the...
Pseudo grayplateletsyndrome was described by Cockbill, Burmester, and Heptinstall (1988) who reported a 25-year-old woman with a history of mild bruising...
is a condition of high platelet (thrombocyte) count in the blood. Normal count is in the range of 150×109 to 450×109 platelets per liter of blood, but...
of granules within platelets are called dense granules. A deficiency of alpha granules is known as grayplateletsyndrome. Platelet rich fibrin Blair P...
alpha-granule biogenesis. Mutation in this gene have been shown to cause grayplateletsyndrome. GRCh38: Ensembl release 89: ENSG00000160796 – Ensembl, May 2017...
Tejapira K, Yongpisarn T, Sakpuwadol N, Suchonwanit P (2022-11-24). "Platelet-rich plasma in alopecia areata and primary cicatricial alopecias: A systematic...
caused by hematopoietic syndrome, increasing mortality. Gastrointestinal. This syndrome often follows absorbed doses of 6–30 grays (600–3,000 rad). The signs...
in Griscelli syndrome.Munc13-4 through its interactions with Rab27a appears to be important for the dense granule release from platelets. The mutated...
Symptoms that develop, like other forms of ALL, relate to deficiency of platelets, resulting in bruising or bleeding; immunosuppression resulting in infections;...
platelets and is released during agitation and vasoconstriction, where it then acts as an agonist to other platelets. About 8% is found in platelets and...
(plasma, platelets, etc.) are transfused over a short period of time. It includes acute lung injury and acute respiratory distress syndrome. (ALI-ARDS)...
associated with Miller–Dieker syndrome. PAFAH1B1 encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acetylhydrolase...
blood cells and platelets is stopped due to loss of the blood-making stem cells (4.5 Gray kills 95% of stem cells). The loss of platelets greatly increases...
jumping from task to task. Reviews of ADHD biomarkers have noted that platelet monoamine oxidase expression, urinary norepinephrine, urinary MHPG, and...
known as dengue hemorrhagic fever or dengue shock syndrome) with bleeding, low levels of blood platelets, blood plasma leakage, and dangerously low blood...
marrow with leukemia cells, which results in a drop in red blood cells, platelets, and normal white blood cells. Diagnosis is generally based on bone marrow...
nephrotic syndrome, there are many other factors that can promote hypercoagulability. Hypercoagulability can be promoted by increased platelet count, enhanced...
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