Supportive care, intravenous fluids, blood transfusions[2]
Frequency
5 million per year (2023)[7]
Deaths
5,000 per year (2023)[7]
Dengue fever is a mosquito-borne tropical disease caused by dengue virus. It is frequently asymptomatic; if symptoms appear they typically begin 3 to 14 days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin itching and skin rash. Recovery generally takes two to seven days. In a small proportion of cases, the disease develops into severe dengue (previously known as dengue hemorrhagic fever or dengue shock syndrome)[8] with bleeding, low levels of blood platelets, blood plasma leakage, and dangerously low blood pressure.[1][2]
Dengue virus has four confirmed serotypes; infection with one type usually gives lifelong immunity to that type, but only short-term immunity to the others. Subsequent infection with a different type increases the risk of severe complications.[9] The symptoms of dengue resemble many other diseases including malaria, influenza, and Zika.[10] Blood tests are available to confirm the diagnosis including detecting viral RNA, or antibodies to the virus.[11]
There is no specific treatment for dengue fever. In mild cases, treatment is focused on treating pain symptoms. Severe cases of dengue require hospitalisation; treatment of acute dengue is supportive and includes giving fluid either by mouth or intravenously.[1][2]
Dengue is spread by several species of female mosquitoes of the Aedes genus, principally Aedes aegypti.[1] Infection can be prevented by mosquito elimination and the prevention of bites.[12] Two types of dengue vaccine have been approved and are commercially available. Dengvaxia became available in 2016 but it is only recommended to prevent re-infection in individuals who have been previously infected.[13] The second vaccine, Qdenga, became available in 2022 and is suitable for adults, adolescents and children from four years of age.[14]
The earliest descriptions of a dengue outbreak date from 1779; its viral cause and spread were understood by the early 20th century.[15] Already endemic in more than one hundred countries, dengue is spreading from tropical and subtropical regions to the Iberian Peninsula and the southern states of the US, partly attributed to climate change.[7][16] It is classified as a neglected tropical disease.[17] During 2023, more than 5 million infections were reported, with more than 5,000 dengue-related deaths.[7] As most cases are asymptomatic or mild, the actual numbers of dengue cases and deaths are under-reported.[7]
^ abcdefgh"Dengue and severe dengue". World Health Organization. 17 March 2023. Archived from the original on 14 March 2024. Retrieved 10 February 2024.
^ abcdefghKularatne SA (September 2015). "BMJ Best Practice Review – Dengue fever". BMJ. 351: h4661. doi:10.1136/bmj.h4661. PMID 26374064. S2CID 1680504.
^dengue Archived 17 July 2022 at the Wayback Machine in the Merriam-Webster Dictionary
^dengue in Oxford Dictionaries
^Nelson Textbook of Pediatrics: The field of pediatrics. Elsevier Health Sciences. 2016. p. 1631. ISBN 978-1-4557-7566-8. Archived from the original on 10 September 2017.
^East S (6 April 2016). "World's first dengue fever vaccine launched in the Philippines". CNN. Archived from the original on 18 October 2016. Retrieved 17 October 2016.
^ abcde"Dengue- Global situation". World Health Organization. Archived from the original on 13 February 2024. Retrieved 13 February 2024.
^Alejandria MM (10 April 2015). "Dengue haemorrhagic fever or dengue shock syndrome in children". BMJ Clinical Evidence. 2015: 0917. ISSN 1752-8526. PMC 4392842. PMID 25860404.
^"Dengue | CDC Yellow Book 2024". Centers for Disease Control and Prevention. 1 May 2023. Archived from the original on 14 February 2024. Retrieved 14 February 2024.
^Schaefer TJ, Panda PK, Wolford RW (14 November 2022). Dengue Fever. Bethesda, MD, USA: StatPearls Publishing. PMID 28613483. Archived from the original on 14 December 2021. Retrieved 13 February 2022.
^"Dengue Diagnosis | CDC". Centers for Disease Control and Prevention. 13 June 2019. Archived from the original on 14 February 2024. Retrieved 14 February 2024.
^"Dengue: How to keep children safe | UNICEF South Asia". www.unicef.org. Archived from the original on 13 February 2024. Retrieved 13 February 2024.
^"Dengue vaccine: WHO position paper – September 2018" (PDF). Weekly Epidemiological Record. 36 (93): 457–76. 7 September 2018. Archived (PDF) from the original on 5 January 2019. Retrieved 12 April 2019.
^"Qdenga | European Medicines Agency". European Medicines Agency. Archived from the original on 27 February 2024. Retrieved 14 February 2024.
^Henchal EA, Putnak JR (October 1990). "The dengue viruses". Clinical Microbiology Reviews. 3 (4): 376–96. doi:10.1128/CMR.3.4.376. PMC 358169. PMID 2224837.
^Paz-Bailey G, Adams LE, Deen J, Anderson KB, Katzelnick LC (February 2024). "Dengue". Lancet. 403 (10427): 667–682. doi:10.1016/S0140-6736(23)02576-X. PMID 38280388. S2CID 267201333.
^"Neglected tropical diseases". World Health Organization. Archived from the original on 26 January 2024. Retrieved 13 February 2024.
Denguefever is a mosquito-borne tropical disease caused by dengue virus. It is frequently asymptomatic; if symptoms appear they typically begin 3 to 14...
As of 2010[update], denguefever is believed to infect 50 to 100 million people worldwide a year with 1/2 million life-threatening infections. It dramatically...
Dengue vaccine is a vaccine used to prevent denguefever in humans. Development of dengue vaccines began in the 1920s, but was hindered by the need to...
Dengue virus (DENV) is the cause of denguefever. It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus...
Hay, S.I.; Graham, A.J. (2006). "The Global Distribution of Yellow Fever and Dengue". Advances in Parasitology. 62: 181–220. doi:10.1016/S0065-308X(05)62006-4...
Egypt"), the yellow fever mosquito, is a mosquito that can spread denguefever, chikungunya, Zika fever, Mayaro and yellow fever viruses, and other disease...
Amarillovirales) includes dengue, yellow fever, and two viruses in the tick-borne encephalitis group that cause VHF: Omsk hemorrhagic fever virus and Kyasanur...
The 2009 Bolivian denguefever epidemic was an epidemic of denguefever which struck Bolivia in early 2009, escalating into a national emergency by February...
previously uninfected people at a somewhat higher risk of a severe case of denguefever through antibody-dependent enhancement. A political controversy erupted...
Zac Holtzman is an American guitarist and co-founder of the band DengueFever. He also played Dr. San in the web series On Cinema, At The Cinema. From...
P.; Ong, B. K. C.; Transfusion-Transmitted Dengue Infection Study Group (2008). "Dengue Hemorrhagic Fever Transmitted by Blood Transfusion". New England...
for denguefever and should be used in conjunction with other tests for a reliable diagnosis. Hess test "Tourniquet test". Halstead SB (2008). Dengue. London:...
the 2020 Summer Olympics. In 2014, Tokyo experienced one of its worst denguefever outbreaks in 100 years and the first recorded cases in 70 years, with...
In the 2005 dengue outbreak in Singapore, a significant rise in the number of denguefever cases was reported in Singapore, becoming the country's worst...
yellow fever mosquito A. aegypti is involved. It is well adapted to urban areas, and can also transmit other diseases, including Zika fever, denguefever, and...
(nonstructural protein 1) is a test for dengue, introduced in 2006. It allows rapid detection on the first day of fever, before antibodies appear some 5 or...
for example, vector-borne diseases like denguefever, malaria, tick-borne diseases, leishmaniasis, zika fever, chikungunya and Ebola. One mechanism contributing...
Langerhans cells are also the initial target of the virus that causes denguefever during its development. During ageing the capacity of Langerhans cells...
but when present they are usually mild and can resemble denguefever. Symptoms may include fever, red eyes, joint pain, headache, and a maculopapular rash...
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as denguefever. Most recently, it rolled out educational home visits, where NEA officers visit homes in areas where there are less than 10 dengue cases...
dengue outbreak in Singapore, a record-breaking number of denguefever cases was reported in Singapore. This was part of the wider 2019–2020 dengue fever...
niʔmɔəl]) is a Cambodian-American singer and lead vocalist for the band DengueFever, which she joined in 2001. Chhom Nimol was born in Cambodia and for a...
In the 2023 dengue outbreak in Jamaica, a significant rise in the number of denguefever cases was reported in Jamaica. In September 2023 The Ministry...