Alpha granules, (α-granules) also known as platelet alpha-granules are a cellular component of platelets. Platelets contain different types of granules that perform different functions, and include alpha granules, dense granules, and lysosomes.[1] Of these, alpha granules are the most common,[1] making up 50% to 80% of the secretory granules.[2] Alpha granules contain several growth factors.[3]
^Heijnen, H.; Sluijs, P. van der (2015). "Platelet secretory behaviour: as diverse as the granules … or not?". Journal of Thrombosis and Haemostasis. 13 (12): 2141–2151. doi:10.1111/jth.13147. PMID 26391322. S2CID 206159932. Retrieved 3 April 2021.
Alphagranules, (α-granules) also known as platelet alpha-granules are a cellular component of platelets. Platelets contain different types of granules...
platelet alpha-granule deficiency, is a rare congenital autosomal recessive bleeding disorder caused by a reduction or absence of alpha-granules in blood...
ultra-large VWF in endothelium (in the Weibel–Palade bodies), megakaryocytes (α-granules of platelets), and subendothelial connective tissue. The basic VWF monomer...
are found only in platelets and are smaller than alphagranules. The origin of these dense granules is still unknown, however, it is thought that may...
maintain their discoid shape. Organelle zone – is rich in platelet granules. Alphagranules contain clotting mediators such as factor V, factor VIII, fibrinogen...
chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood...
eosinophilic or "acid-loving" due to their large acidophilic cytoplasmic granules, which show their affinity for acids by their affinity to coal tar dyes:...
low-molecular-weight kininogen. Plasmin has been shown to interact with Thrombospondin 1, Alpha 2-antiplasmin and IGFBP3. Moreover, plasmin induces the generation of bradykinin...
In cellular biology, stress granules are biomolecular condensates in the cytosol composed of proteins and RNAs that assemble into 0.1–2 μm membraneless...
small GTPases is a signal transduction pathway that triggers platelet alpha-granule release". Cell. 115 (7): 851–862. doi:10.1016/S0092-8674(03)01014-6...
PMID 10567433. Altura BM (Jun 1975). "Pharmacological effects of alpha-methyldopa, alpha-methylnorepinephrine, and octopamine on rat arteriolar, arterial...
KL, Marshall-Carlson L, Bainton DF (July 1989). "GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells...
alpha-granules[citation needed] one of three types of platelet secretory granule Platelet α–granules are important in platelet activity, α–granules connect...
the dense granules and alphagranules. From the dense granules, serotonin and adenosine diphosphate are released. From the alphagranules come molecules...
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are...
defect in the secretion of the granule contents in neutrophils. There are other causes for a congenital platelet alpha-granule-deficient bleeding disorder...
stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified...
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