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Mean platelet volume
Purpose
can be used to make inferences about platelet production in bone marrow or platelet destruction problems
Mean platelet volume (MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems.[1]
An increased mean platelet volume (MPV) increases the risk to suffer a heart disease [2]
MPV may be higher when there is destruction of platelets. This may be seen in immune thrombocytopenic purpura (ITP), myeloproliferative diseases and Bernard–Soulier syndrome. It may also be related to pre-eclampsia and recovery from transient hypoplasia.[3]
Abnormally low MPV values may correlate with thrombocytopenia when it is due to impaired production of megakaryocytes in the bone marrow, such as in aplastic anemia. A low MPV may indicate inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis.[4] A high MPV is also a bad prognostic marker in patients with sepsis or septic shock.[5][6] In addition, low MPV may correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as Wiskott–Aldrich syndrome (WAS),[7] caused by a genetic mutation of the WAS gene.
Sample for MPV testing is obtained in a Lavender-Top EDTA tube. A typical range of platelet volumes is 9.4–12.3 fL[8] (femtolitre), equivalent to spheres 2.65 to 2.9 µm in diameter.
^"Complete Blood Count (CBC)". Testing.com.
^Slavka, Georg; Perkmann, Thomas; Haslacher, Helmuth; Greisenegger, Stefan; Marsik, Claudia; Wagner, Oswald F.; Endler, Georg (February 2012). "Mean Platelet Volume May Represent a Predictive Parameter for Overall Vascular Mortality and Ischemic Heart Disease". Arteriosclerosis, Thrombosis, and Vascular Biology. 31 (5): 1215–1218. doi:10.1161/ATVBAHA.110.221788. PMID 21330610. S2CID 85367.
^Lippi G, Filippozzi L, Salvagno GL, Montagnana M, Franchini M, Guidi GC, Targher G (September 2009). "Increased mean platelet volume in patients with acute coronary syndromes". Archives of Pathology & Laboratory Medicine. 133 (9): 1441–3. doi:10.5858/133.9.1441. PMID 19722752.
^Liu S, Ren J, Han G, Wang G, Gu G, Xia Q, Li J (October 2012). "Mean platelet volume: a controversial marker of disease activity in Crohn's disease". European Journal of Medical Research. 17 (1): 27. doi:10.1186/2047-783x-17-27. PMC 3519557. PMID 23058104.
^Mangalesh S, Dudani S, Malik A (March 2021). "Platelet Indices and Their Kinetics Predict Mortality in Patients of Sepsis". Indian Journal of Hematology & Blood Transfusion. 37 (4): 600–608. doi:10.1007/s12288-021-01411-2. PMC 7988247. PMID 33776267.
^Gao Y, Li Y, Yu X, Guo S, Ji X, Sun T, et al. (2014-08-13). Stover CM (ed.). "The impact of various platelet indices as prognostic markers of septic shock". PLOS ONE. 9 (8): e103761. Bibcode:2014PLoSO...9j3761G. doi:10.1371/journal.pone.0103761. PMC 4131909. PMID 25118886.
Meanplateletvolume (MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests...
thrombocytopenic purpura (ITP), and characterized by low platelet count, but high MPV (meanplateletvolume). Caused by glycoprotein abnormalities: Bernard–Soulier...
Harris platelet syndrome, authors found a statistically higher meanplateletvolume, red cell distribution width, lower platelet count and platelet biomass...
an image generator for serious simulation Meanplateletvolume, in blood testing, a measure of platelet size Meerwein–Ponndorf–Verley reduction, a chemical...
individual with platelet storage pool deficiency is as follows: Unusual bleeding(after surgical procedure) Anemia Decrease meanplateletvolume Myelodysplasia...
white blood cells, red blood cells and platelets, the concentration of hemoglobin, and the hematocrit (the volume percentage of red blood cells). The red...
Mazzara R, Cid J, Jou JM, Marín JL, Ordinas A (1998). "[Platelet count and meanplateletvolume in the Spanish population]". Med Clin (Barc) (in Spanish)...
E., Uysal, B, A., Dogan, A., Ozaydin, M. and Erodogan, D. (2012) Meanplateletvolume as a prognostic value in patients with coronary artery ectasia. Clin...
results, along with hemoglobin concentration, white blood cell count and platelet count. Because the purpose of red blood cells is to transfer oxygen from...
an elevated WBC count, agglutinated RBCs, RBC fragments, giant platelets or platelet clumps. In addition, it is a characteristic feature of bovine blood...
Mean corpuscular hemoglobin concentrations WBC differential count in percentage and absolute value Platelet distribution width Plateletmeanvolume Large...
genome-wide association study identifies three loci associated with meanplateletvolume. Am J Hum Genet 2009; 84: 66 - 71 Newton-Cheh C, Johnson T, Gateva...
the equivalent of between six and ten random platelet concentrates. Quality control demands the platelets from apheresis be equal to or greater than 3...
thromboxane A, it does not appear to do so at levels that would interfere with platelet function. A pooled analysis of randomized, controlled studies of meloxicam...
disorder. Additionally, SNPs located in TMEM81 affect thrombopoiesis, meanplateletvolume, and have been implicated in Meniere’s disease. The 1q32.1 region...
(myeloproliferative neoplasm) characterised by the overproduction of platelets (thrombocytes) by megakaryocytes in the bone marrow. It may, albeit rarely...
components of the blood, such as red blood cells, white blood cells, plasma, platelets, and other clotting factors. Red blood cells (RBC) contain hemoglobin...
hypothermia. The activity of coagulation factors, fibrinogen depletion, and platelet quantity are all adversely affected by acidosis. Hypothermia (less than...
bleeding. Thrombocytopaenia means there is low plateletvolume in the blood. This means there are less platelets to coagulate in presence of a damaged blood...
of blood, and lab abnormalities such as elevated liver enzymes or low platelet counts. Treatment is directed towards decreasing portal hypertension itself...
(eight weeks) between whole-blood donations but only seven days between platelet apheresis donations and twice per seven-day period in plasmapheresis. The...
and hemoglobin levels Increased mean corpuscular volume (MCV, >100 fL) and mean corpuscular hemoglobin (MCH) Normal mean corpuscular hemoglobin concentration...
term. The effect of pregnancy on platelet count is unclear, with some studies demonstrating a mild decline in platelet count and other studies that show...
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