Two giant platelets (stained purple) are visible in this image from a light microscope (40×) from a peripheral blood smear surrounded by red blood cells. One normal platelet can be seen in the upper left side of the image (purple) and is significantly smaller in size than the red blood cells (stained pink).
Specialty
Hematology
Giant platelet disorders, also known as macrothrombocytopenia, are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding. Giant platelets cannot stick adequately to injured blood vessel walls, resulting in abnormal bleeding when injured. Giant platelet disorder occurs for inherited diseases like Bernard–Soulier syndrome, gray platelet syndrome and May–Hegglin anomaly.[1]
^Loscalzo, Joseph; Schafer, Andrew I. (2003). Thrombosis and Hemorrhage. Lippincott Williams & Wilkins. p. 317. ISBN 9780781730662. Retrieved 13 November 2017.
and 23 Related for: Giant platelet disorder information
Giantplateletdisorders, also known as macrothrombocytopenia, are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency...
Harris platelet syndrome, previously known as asymptomatic constitutional macrothrombocytopenia, is the most common inherited giantplateletdisorder in the...
Gray platelet syndrome (GPS), or platelet alpha-granule deficiency, is a rare congenital autosomal recessive bleeding disorder caused by a reduction or...
initials related to diseases (infectious or non-infectious) and medical disorders. Acronyms in healthcare List of medical abbreviations: Overview List of...
practice guidelines and a normal bleeding time does not exclude a plateletdisorder. Bone marrow examination may be performed on patients over the age...
function tests, are abnormal particularly raised ALP- alkaline phosphatase Platelets may also be elevated The gold standard for diagnosing temporal arteritis...
associated with Bernard–Soulier syndrome, velocardiofacial syndrome and giantplateletdisorder. The 206 amino acid precursor of GPIb beta is synthesized from...
which happens after the initial platelet aggregation but before the formation of fibrin and stable aggregated platelet products. Common anticoagulants...
reach the size of an erythrocytes. This large platelet size can be compared with MYH9 disorders where platelet size can vary between 4.5 um and the 6.6 um...
to manage. In this article, the term temporomandibular disorder is taken to mean any disorder that affects the temporomandibular joint, and temporomandibular...
circulating platelets (i.e. thrombocytopenia), anemia due to reduced production of red blood cells, and/or other signs or symptoms of the disorder. However...
histamine, which then leads to the release of cytokines, prostaglandins, and platelet-activating factor. Mast cell intermediaries cause an allergic inflammation...
own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated...
and topical guide to cardiology, the branch of medicine dealing with disorders of the human heart. The field includes medical diagnosis and treatment...
P. S.; Feldman, B. F.; et al. (2005). "Platelets: Overview, Morphology, Quantity, Platelet Function Disorders (Thrombocytopathia or Thrombopathia)". A...
t(17;22). The translocation fuses the collagen gene (COL1A1) with the platelet-derived growth factor (PDGF) gene. The fibroblast, the cell of origin of...
low white blood cell count, especially of lymphocytes, as well as a low platelet count. These signs may or may not be accompanied by anorexia, a runny nose...
(a shortage of red blood cells), a high white blood cell count, a high platelet count, allergic reactions, immune complexes, antibodies (tools the body...
categorized as other conditions. Notably, conditions associated with giantplatelets and associated with mutations of MYH9 are no longer considered to be...
group; ** = not listed on hcdm Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest 2005; 115:3363-9. "FITC Anti-human...
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