Transmission electron micrograph of a microvessel displaying pericytes that are lining the outer surface of endothelial cells that are encircling an erythrocyte (E).
Details
Identifiers
Latin
pericytus
MeSH
D020286
TH
H3.09.02.0.02006
FMA
63174
Anatomical terms of microanatomy
[edit on Wikidata]
Pericytes (formerly called Rouget cells)[1] are multi-functional mural cells of the microcirculation that wrap around the endothelial cells that line the capillaries throughout the body.[2] Pericytes are embedded in the basement membrane of blood capillaries, where they communicate with endothelial cells by means of both direct physical contact and paracrine signaling.[3] The morphology, distribution, density and molecular fingerprints of pericytes vary between organs and vascular beds.[4][5] Pericytes help to maintain homeostatic and hemostatic functions in the brain, one of the organs with higher pericyte coverage, and also sustain the blood–brain barrier.[6] These cells are also a key component of the neurovascular unit, which includes endothelial cells, astrocytes, and neurons.[7][8] Pericytes have been postulated to regulate capillary blood flow [9][10][11][12] and the clearance and phagocytosis of cellular debris in vitro.[13] Pericytes stabilize and monitor the maturation of endothelial cells by means of direct communication between the cell membrane as well as through paracrine signaling.[14] A deficiency of pericytes in the central nervous system can cause increased permeability of the blood–brain barrier.[6]
^Dore-Duffy, P. (2008). "Pericytes: Pluripotent cells of the blood brain barrier". Current Pharmaceutical Design. 14 (16): 1581–93. doi:10.2174/138161208784705469. PMID 18673199.
^Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O (January 2015). "Pericytes at the intersection between tissue regeneration and pathology". Clinical Science. 128 (2): 81–93. doi:10.1042/CS20140278. PMC 4200531. PMID 25236972.
^Bergers G, Song S (October 2005). "The role of pericytes in blood-vessel formation and maintenance". Neuro-Oncology. 7 (4): 452–64. doi:10.1215/S1152851705000232. PMC 1871727. PMID 16212810.
^Sims, David E. (January 1986). "The pericyte—A review". Tissue and Cell. 18 (2): 153–174. doi:10.1016/0040-8166(86)90026-1. PMID 3085281.
^ abWinkler EA, Bell RD, Zlokovic BV (October 2011). "Central nervous system pericytes in health and disease". Nature Neuroscience. 14 (11): 1398–1405. doi:10.1038/nn.2946. PMC 4020628. PMID 22030551.
^Dore-Duffy P, Cleary K (2011). "Morphology and properties of pericytes". The Blood-Brain and Other Neural Barriers. Methods in Molecular Biology. Vol. 686. pp. 49–68. doi:10.1007/978-1-60761-938-3_2. ISBN 978-1-60761-937-6. PMID 21082366.
^Liebner S, Czupalla CJ, Wolburg H (2011). "Current concepts of blood-brain barrier development". The International Journal of Developmental Biology. 55 (4–5): 467–76. doi:10.1387/ijdb.103224sl. PMID 21769778.
^Hartmann, David A.; Berthiaume, Andrée-Anne; Grant, Roger I.; Harrill, Sarah A.; Koski, Tegan; Tieu, Taryn; McDowell, Konnor P.; Faino, Anna V.; Kelly, Abigail L.; Shih, Andy Y. (May 2021). "Brain capillary pericytes exert a substantial but slow influence on blood flow". Nature Neuroscience. 24 (5): 633–645. doi:10.1038/s41593-020-00793-2. ISSN 1097-6256. PMC 8102366. PMID 33603231.
^Cite error: The named reference :0 was invoked but never defined (see the help page).
^Cite error: The named reference Hall-2014 was invoked but never defined (see the help page).
^Cite error: The named reference Peppiatt-2006 was invoked but never defined (see the help page).
^Rustenhoven, Justin; Smyth, Leon C.; Jansson, Deidre; Schweder, Patrick; Aalderink, Miranda; Scotter, Emma L.; Mee, Edward W.; Faull, Richard L. M.; Park, Thomas I.-H.; Dragunow, Mike (December 2018). "Modelling physiological and pathological conditions to study pericyte biology in brain function and dysfunction". BMC Neuroscience. 19 (1): 6. doi:10.1186/s12868-018-0405-4. ISSN 1471-2202. PMC 5824614. PMID 29471788.
^Fakhrejahani E, Toi M (2012). "Tumor angiogenesis: pericytes and maturation are not to be ignored". Journal of Oncology. 2012: 1–10. doi:10.1155/2012/261750. PMC 3191787. PMID 22007214.
Pericytes (formerly called Rouget cells) are multi-functional mural cells of the microcirculation that wrap around the endothelial cells that line the...
Wang ZM, Messi ML, Olson JD, Mintz A, Delbono O (July 2014). "Type-2 pericytes participate in normal and tumoral angiogenesis". Am. J. Physiol., Cell...
blood cell, E) within its lumen, endothelial cells forming its tunica intima (inner layer), and pericytes forming its tunica adventitia (outer layer)....
cortex, with additional amounts being produced in the liver, and the pericytes in the brain. Regulation is believed to rely on a feedback mechanism measuring...
perisinusoidal cells or Ito cells (earlier lipocytes or fat-storing cells), are pericytes found in the perisinusoidal space of the liver, also known as the space...
endothelium and many of them are surrounded by contractile cells called pericytes. The endothelium provides a smooth surface for the flow of blood and regulates...
of cells), fibro-adipogenic progenitors (FAPs)(20%), pericytes (14%) and endothelial-like pericytes (4%). Another 9% of mononuclear cells are muscle stem...
as they do in other capillaries; this creates the blood–brain barrier. Pericytes play a major role in the formation of the tight junctions. The barrier...
too small to have a smooth muscle layer and are instead supported by pericytes that wrap around them. Post-capillary venules become muscular venules...
layers: The glomerular membrane consists of mesangial cells, modified pericytes that in other parts of the body separate capillaries from each other....
Lacis cells, Polkissen cells, or Goormaghtigh cells) are light-staining pericytes in the kidney found outside the glomerulus, near the vascular pole. They...
amino acids and has a mass of 37 kDa. The enzyme renin is secreted by pericytes in the vicinity of the afferent arterioles and similar microvessels of...
1987). "The glomerular mesangial cell: an expanding role for a specialized pericyte". The FASEB Journal. 1 (4): 272–81. doi:10.1096/fasebj.1.4.3308611. PMID 3308611...
hemangiopericytoma is a type of soft-tissue sarcoma that originates in the pericytes in the walls of capillaries. When inside the nervous system, although...
Files DC, Mannava S, Smith T, Wang ZM, et al. (November 2014). "Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent...
Endothelial colony forming cell Endothelial stem cell Angioblast/Mesoangioblast Pericyte Mural cell Mesothelial cell Pneumocyte Type I cell Type II cell Club cell...
Olson, John D.; Mintz, Akiva; Delbono, Osvaldo (2014-07-01). "Type-2 pericytes participate in normal and tumoral angiogenesis". American Journal of Physiology...
Files DC, Mannava S, Smith T, Wang ZM, et al. (November 2014). "Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent...
are too small to contain smooth muscle. They are instead supported by pericytes that wrap around them. When the post-capillary venules increase in diameter...
vascular mural cells), the vasomotor apparatus (smooth muscle cells and pericytes), and microglia. Together these function in the homeostatic haemodynamic...
band of contractile mural cells either classified as smooth muscle or pericytes that adjusts blood flow into capillaries. They were originally described...
between the 2 new vessels at the zone of contact that is filled with pericytes and myofibroblasts. These cells begin laying collagen fibers into the...
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