Neuromyelitis optica spectrum disorders (NMOSD) are a spectrum of autoimmune diseases characterized by acute inflammation of the optic nerve (optic neuritis, ON) and the spinal cord (myelitis).[1][2][3] Episodes of ON and myelitis can be simultaneous or successive. A relapsing disease course is common, especially in untreated patients.[1][4]
Neuromyelitis optica (NMO) is a particular disease within the NMOSD spectrum. It is characterised by optic neuritis and longitudinally extensive myelitis. In more than 80% of NMO cases, the cause is immunoglobulin G autoantibodies to aquaporin 4 (anti-AQP4), the most abundant water channel protein in the central nervous system.[5][1][4]
Less common diseases with other manifestations are also part of the NMOSD spectrum.[6][4]
^Banerjee S, Butcher R. Rituximab for the Treatment of Neuromyelitis Optica Spectrum Disorder [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2021 Feb. Available from: https://www.ncbi.nlm.nih.gov/books/NBK571350/
^"Neuromyelitis optica – Symptoms and causes". Mayo Clinic. Retrieved 2020-08-01.
Neuromyelitisopticaspectrumdisorders (NMOSD) are a spectrum of autoimmune diseases characterized by acute inflammation of the optic nerve (optic neuritis...
neuritis due to the broad range of alternative causes, such as neuromyelitisopticaspectrumdisorder (NMOSD), and other autoimmune or infectious conditions....
processes in many diseases such as multiple sclerosis, neuromyelitisopticaspectrumdisorder (NMOSD), diabetes, atherosclerosis, gastric cancer, depression...
Nakamura S, Tamashiro K, Fujihara K (May 2016). "[Anti-MOG + neuromyelitisopticaspectrumdisorders treated with plasmapheresis]". No to Hattatsu = Brain and...
international consensus diagnostic criteria for what became termed neuromyelitisopticaspectrumdisorder (NMO-SD). She has also worked to determine the best treatment...
monoclonal antibody medication that is used for the treatment of neuromyelitisopticaspectrumdisorder (NMOSD), a rare autoimmune disease. The drug is being developed...
brand name Uplizna, is a medication for the treatment of neuromyelitisopticaspectrumdisorder (NMOSD) in adults. Inebilizumab is a humanized mAb that...
Sakurai K, Shibuya M, Kubo K, et al. (9 December 2013). "Neuromyelitisopticaspectrumdisorder complicated with Sjogren syndrome successfully treated with...
Giovanna S.; Levy, Michael (November 2020). "Update on neuromyelitisopticaspectrumdisorder". Current Opinion in Ophthalmology. 31 (6): 462–468. doi:10...
leukemia, or aplastic anemia. Eculizumab is also used to treat neuromyelitisopticaspectrumdisorder in adults who are anti-aquaporin-4 (AQP4) antibody positive...
drug cladribine, used in generalised myasthenia gravis and neuromyelitisopticaspectrumdisorder. In September 2017, Merck said it is considering options...
diagnosis of acute TM includes demyelinating disorders, such as multiple sclerosis and neuromyelitisoptica, infections, such as herpes zoster and herpes...
exacerbate Japanese opticspinal MS in neuromyelitisopticaspectrum: Japanese optic-spinal MS: Is it MS or neuromyelitisoptica and does the answer dictate treatment...
ophthalmoplegia Wall M, Wray S (1983). "The one-and-a-half syndrome--a unilateral disorder of the pontine tegmentum: a study of 20 cases and review of the literature"...
hepatitis), and neurological diseases (myasthenia gravis, neuromyelitisopticaspectrumdisorders (NMOSD), and multiple sclerosis). For men who may develop...
initials related to diseases (infectious or non-infectious) and medical disorders. Acronyms in healthcare List of medical abbreviations: Overview List of...
"Repeated Non-enhancing Tumefactive Lesions in a Patient with a NeuromyelitisOpticaSpectrumDisorder". Internal Medicine. 50 (9): 1061–1064. doi:10.2169/internalmedicine...
one of the underlying conditions for the phenotype neuromyelitisoptica and in general all the spectrum of MOG autoantibody-associated demyelinating diseases...
Fiber Layer Thickness and Macular Volume in Patients with NeuromyelitisOpticaSpectrumDisorder". Journal of Neuro-Ophthalmology. 36 (4): 363–368. doi:10...
pattern III in the MS spectrum. They have been reported alone, but also associated to standard multiple sclerosis, neuromyelitisoptica, CADASIL and progressive...
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