Gestrinone, sold under the brand names Dimetrose and Nemestran among others, is a medication which is used in the treatment of endometriosis.[3][4] It has also been used to treat other conditions such as uterine fibroids and heavy menstrual bleeding and has been investigated as a method of birth control.[5][6][1] Gestrinone is used alone and is not formulated in combination with other medications.[7] It is taken by mouth or in through the vagina.[1][8]
Side effects of gestrinone include menstrual abnormalities, estrogen deficiency, and symptoms of masculinization like acne, seborrhea, breast shrinkage, increased hair growth, and scalp hair loss, among others.[1][8][9][10] Gestrinone has a complex mechanism of action, and is characterized as a mixed progestogen and antiprogestogen, a weak androgen and anabolic steroid, a weak antigonadotropin, a weak steroidogenesis inhibitor, and a functional antiestrogen.[11][1][12][13]
Gestrinone was introduced for medical use in 1986.[14] It has been used extensively in Europe but appears to remains marketed only in a few countries throughout the world.[10][15][7] The medication is not available in the United States.[16] Due to its anabolic effects, the use of gestrinone in competition has been banned by the International Olympic Committee.[17]
^ abcdefghiThomas EJ, Rock J (6 December 2012). Modern Approaches to Endometriosis. Springer Science & Business Media. pp. 228, 232, 234. ISBN 978-94-011-3864-2.
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-15.
^Coutinho EM (1990). "Therapeutic experience with gestrinone". Prog. Clin. Biol. Res. 323: 233–40. PMID 2406749.
^Cite error: The named reference MortonHall1999 was invoked but never defined (see the help page).
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^Cite error: The named reference pmid14717620 was invoked but never defined (see the help page).
^ abCite error: The named reference Drugs.com was invoked but never defined (see the help page).
^ abCite error: The named reference Carp2015 was invoked but never defined (see the help page).
^Cite error: The named reference DesaiPatel2012 was invoked but never defined (see the help page).
^ abCite error: The named reference BlackwellOlive2012 was invoked but never defined (see the help page).
^Cite error: The named reference Berek2007 was invoked but never defined (see the help page).
^Carp HJ (9 April 2015). Progestogens in Obstetrics and Gynecology. Springer. pp. 141–. ISBN 978-3-319-14385-9.
^Bromham DR, Booker MW, Rose GL, Wardle PG, Newton JR (1995). "A multicentre comparative study of gestrinone and danazol in the treatment of endometriosis". Journal of Obstetrics and Gynaecology. 15 (3): 188–194. doi:10.3109/01443619509015498. ISSN 0144-3615.
^Cite error: The named reference AcademicPress1988 was invoked but never defined (see the help page).
^Cite error: The named reference Index Nominum2000 was invoked but never defined (see the help page).
^Cite error: The named reference LedgerSchlaff2014 was invoked but never defined (see the help page).
^"Helping athletes compete drug-free" (PDF). Canadian Centre for Ethics in Sport. May 2000. p. 34. Archived from the original (PDF) on 2006-05-17. Retrieved 2006-06-01.
Gestrinone, sold under the brand names Dimetrose and Nemestran among others, is a medication which is used in the treatment of endometriosis. It has also...
entered mass production, and the banned anabolic steroids trenbolone and gestrinone, the latter of which was used to synthesize it. In 2003, whistleblower...
with progestational agents (i.e., medroxyprogesterone acetate), danazol, gestrinone, or gonadotropin-releasing hormone agonists (GnRH), as well as other less...
antagonists: Androgen: cyproterone acetate Progestins: mifepristone, gestrinone Steroid hormones are transported through the blood by being bound to carrier...
HPG axis), as well as steroid synthesis inhibitors such as danazol and gestrinone. Since progestins have relatively little effect on sexual differentiation...
counteracts estrogen and inhibits the growth of the endometrium. Danazol and gestrinone are suppressive steroids with some androgenic activity. Both agents inhibit...
molecular formula C21H24O2 (molar mass: 308.414 g/mol) may refer to: Gestrinone Tosagestin, or 11-methylene-δ15-norethisterone This set index page lists...
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