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Triptorelin information


Triptorelin
Clinical data
Trade namesDecapeptyl, others
AHFS/Drugs.comMicromedex Detailed Consumer Information
License data
  • US DailyMed: Triptorelin
Routes of
administration		Intramuscular
Drug classGnRH analogue; GnRH agonist; Antigonadotropin
ATC code
  • L02AE04 (WHO) QH01CA97 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)[1]
  • CA: ℞-only
  • US: ℞-only[2]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
ExcretionKidney
Identifiers
IUPAC name
  • 5-oxo-D-prolyl-L-histidyl-Ltryptophyl-L-seryl-Ltyrosyl-3-(1H-indol-2-yl)-L-alanylleucyl-L-arginyl-L-prolylglycinamide
CAS Number
  • 57773-63-4 ☒N
PubChem CID
  • 25074470
IUPHAR/BPS
  • 1177
DrugBank
  • DB06825 ☒N
ChemSpider
  • 17290424 ☒N
UNII
  • 9081Y98W2V
KEGG
  • D06247 ☒N
  • D08649
ChEBI
  • CHEBI:63633 ☒N
ChEMBL
  • ChEMBL1201334 ☒N
CompTox Dashboard (EPA)
  • DTXSID2048375 Edit this at Wikidata
ECHA InfoCard100.165.044 Edit this at Wikidata
Chemical and physical data
FormulaC64H82N18O13
Molar mass1311.473 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CC(C)C[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)[C@@H](Cc2c[nH]c3c2cccc3)NC(=O)[C@H](Cc4ccc(cc4)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc5c[nH]c6c5cccc6)NC(=O)[C@H](Cc7cnc[nH]7)NC(=O)[C@@H]8CCC(=O)N8
InChI
  • InChI=1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1 ☒N
  • Key:VXKHXGOKWPXYNA-PGBVPBMZSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Triptorelin, sold under the brand name Decapeptyl among others, is a medication that acts as an agonist analog of gonadotropin-releasing hormone, repressing expression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).[3][4]

It is a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2) and a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts.

Primary indications include endometriosis,[5] for the reduction of uterine fibroids, to treat prostate cancer, and to treat male hypersexuality with severe sexual deviation.[4] The drug has also been used off label to delay puberty in patients with gender dysphoria.[6]

It was patented in 1975 and approved for medical use in 1986.[7] It is on the World Health Organization's List of Essential Medicines.[8]

  1. ^ "Prescription medicines: registration of new chemical entities in Australia, 2015". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.
  2. ^ "Triptodur- triptorelin kit". DailyMed. U.S. National Library of Medicine. 28 April 2022. Retrieved 15 May 2022.
  3. ^ "gonadorelin analogue". Encyclopedia.com. Retrieved 2019-09-21.
  4. ^ a b Joint Formulary Committee (2018). British National Formulary (BNF) 70. London: Pharmaceutical Press. p. 635. ISBN 978-0-85711-173-9.
  5. ^ Leone Roberti Maggiore U, Scala C, Remorgida V, Venturini PL, Del Deo F, Torella M, et al. (June 2014). "Triptorelin for the treatment of endometriosis". Expert Opinion on Pharmacotherapy. 15 (8). Informa Healthcare: 1153–1179. doi:10.1517/14656566.2014.916279. PMID 24832495. S2CID 23843087.
  6. ^ Cohen D, Barnes H (September 2019). "Gender dysphoria in children: puberty blockers study draws further criticism". BMJ. 366: l5647. doi:10.1136/bmj.l5647. PMID 31540909. S2CID 202711942.
  7. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 514. ISBN 9783527607495.
  8. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

and 24 Related for: Triptorelin information

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Triptorelin

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Triptorelin, sold under the brand name Decapeptyl among others, is a medication that acts as an agonist analog of gonadotropin-releasing hormone, repressing...

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Debiopharm

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1982, it began to focus on triptorelin, after having acquired the rights for its development from Tulane University. Triptorelin is a Gonadotropin-releasing...

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Precocious puberty

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possible treatment is with anastrozole. GnRH agonists, including histrelin, triptorelin, or leuprorelin, are other possible treatments. Non-continuous use[clarification...

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WHO Model List of Essential Medicines

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inhibitors) Flutamide and nilutamide are alternatives Goserelin and triptorelin are alternatives Prednisone is an alternative Biscuit or paste of nutritional...

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Prostate cancer

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treatment typically involves GnRH agonists like leuprolide, goserelin, or triptorelin by injection monthly or less frequently as needed. GnRH agonists cause...

Word Count : 8858

Luteinizing hormone

Last Update:

Goserelin Histrelin Lecirelin Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide:...

Word Count : 3474

Menstrual cycle

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menstrual cycle occurring. This may be achieved using medroxyprogesterone, triptorelin or goserelin, or by sustained use of oral contraceptives. Hormonal contraceptives...

Word Count : 6257

Orchiectomy

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medical castration include, euprolide, goserelin (Zoladex), buserelin, and triptorelin (Trelstar). Some of the side effects of these medications include but...

Word Count : 3625

Ferring Pharmaceuticals

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endocrinology. Reproductive medicine and maternal health / Fertility Triptorelin, which Ferring markets as Gonapeptyl or Decapeptyl in some countries...

Word Count : 1712

Leuprorelin

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failure in women receiving cyclophosphamide for chemotherapy. Along with triptorelin and goserelin, it has been used to delay puberty in transgender youth...

Word Count : 3632

Menotropin

Last Update:

Goserelin Histrelin Lecirelin Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide:...

Word Count : 881

Chemical castration

Last Update:

hormone agonists. Leuprorelin Neutersol Nonsurgical neutering alternatives Triptorelin "Can Castration Be a Solution for Sex Offenders? Man Who Mutilated Himself...

Word Count : 5304

Breast cancer

Last Update:

estrogen production with GnRH-targeted drugs (goserelin, leuprolide, or triptorelin) and aromatase inhibitors (anastrozole, letrozole, or exemestane) slightly...

Word Count : 15821

Ipsen

Last Update:

thyroid cancer (RAI-R DTC) after prior systemic therapy Decapeptyl (triptorelin) is an analogue of the natural gonadotropin-releasing hormone (GnRH)...

Word Count : 2137

Human chorionic gonadotropin

Last Update:

Goserelin Histrelin Lecirelin Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide:...

Word Count : 5369

Antigonadotropin

Last Update:

Goserelin Histrelin Lecirelin Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide:...

Word Count : 794

Gonadotropin preparations

Last Update:

Goserelin Histrelin Lecirelin Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide:...

Word Count : 1654

Gonadotropin

Last Update:

Goserelin Histrelin Lecirelin Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide:...

Word Count : 1114

Puberty blocker

Last Update:

the GnRH agonists buserelin, histrelin, leuprorelin, nafarelin, and triptorelin. GnRH agonists are available and used as daily subcutaneous injections...

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Orazio Schillaci

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of the drug triptorelin." LGBTQIA+ associations protested the retaliatory and discriminatory actions that affect human rights. [Triptorelin is a puberty-blocking...

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Androgen deprivation therapy

Last Update:

androgen deprivation therapy include leuprorelin (leuprolide), goserelin, triptorelin, histrelin, buserelin, and degarelix. These drugs are injected under...

Word Count : 2100

Transgender hormone therapy

Last Update:

Goserelin Histrelin Lecirelin Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide:...

Word Count : 3633

ATC code L02

Last Update:

Gestonorone L02AE01 Buserelin L02AE02 Leuprorelin L02AE03 Goserelin L02AE04 Triptorelin L02AE05 Histrelin L02AE51 Leuprorelin and bicalutamide L02BA01 Tamoxifen...

Word Count : 239

Buserelin

Last Update:

Goserelin Histrelin Lecirelin Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide:...

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