Chemical compound
Abarelix Trade names Plenaxis AHFS/Drugs.com Monograph Routes of administration Intramuscular injection Drug class GnRH analogue; GnRH antagonist; Antigonadotropin ATC code Protein binding 96–99%
N-acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-D-asparagyl-L-leucyl-N6-isopropyl-L-lysyl-L-prolyl-D-alaninamide[1]
CAS Number 183552-38-7 N PubChem CID IUPHAR/BPS DrugBank DB00106 Y ChemSpider 10482301 Y UNII KEGG D02738 Y ChEBI CHEBI:337298 Y ChEMBL ChEMBL1252 Y CompTox Dashboard (EPA ) DTXSID20171443 Formula C 72 H 95 Cl N 14 O 14 Molar mass 1416 .09 g·mol−1 3D model (JSmol)
CC(C)C[C@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@@H](NCc5ccc4ccccc4c5)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N6CCC[C@H]6C(=O)N[C@H](C)C(N)=O
InChI=1S/C72H95ClN14O14/c1-41(2)32-54(64(93)80-53(17-10-11-30-77-42(3)4)72(101)87-31-13-18-60(87)69(98)78-43(5)63(75)92)81-68(97)58(38-62(74)91)84-70(99)61(37-46-22-27-52(90)28-23-46)86(7)71(100)59(40-88)85-67(96)57(36-48-14-12-29-76-39-48)83-66(95)56(34-45-20-25-51(73)26-21-45)82-65(94)55(79-44(6)89)35-47-19-24-49-15-8-9-16-50(49)33-47/h8-9,12,14-16,19-29,33,39,41-43,53-61,77,88,90H,10-11,13,17-18,30-32,34-38,40H2,1-7H3,(H2,74,91)(H2,75,92)(H,78,98)(H,79,89)(H,80,93)(H,81,97)(H,82,94)(H,83,95)(H,84,99)(H,85,96)/t43-,53+,54+,55-,56-,57-,58-,59+,60+,61+/m1/s1
Y Key:AIWRTTMUVOZGPW-HSPKUQOVSA-N
Y
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Abarelix , sold under the brand name Plenaxis , is an injectable gonadotropin-releasing hormone antagonist (GnRH antagonist) which is marketed in Germany and the Netherlands. It is primarily used in oncology to reduce the amount of testosterone made in patients with advanced symptomatic prostate cancer for which no other treatment options are available.[2] [3]
It was originally marketed by Praecis Pharmaceuticals as Plenaxis ,[2] and is now marketed by Speciality European Pharma in Germany[4] after receiving a marketing authorization in 2005. The drug was introduced in the United States in 2003, but was discontinued in this country in May 2005 due to poor sales and a higher-than-expected incidence of severe allergic reactions.[5] It remains marketed in Germany and the Netherlands however.[6]
^ "Abarelix". PubChem . 2017-07-29.
^ a b "Abarelix". Drugs.com . Archived from the original on 2018-02-10. Retrieved 2018-01-23 .
^
^ Pharmazeutische Zeitung online: Abarelix (in German)
^ Minev B (13 January 2011). Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures . Springer Science & Business Media. pp. 182–. ISBN 978-90-481-9704-0 .
^ "Abarelix". Drugs.com . Archived from the original on 2019-08-29. Retrieved 2018-08-27 .
Last Update: 2024-02-08T21:04:37Z
Abarelix , sold under the brand name Plenaxis, is an injectable gonadotropin-releasing hormone antagonist (GnRH antagonist) which is marketed in Germany...
Word Count : 237
Last Update: 2024-05-11T12:56:01Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 3474
Last Update: 2023-09-03T18:25:08Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 881
Last Update: 2024-03-18T05:57:34Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 5369
Last Update: 2024-03-31T02:55:33Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 1654
Last Update: 2022-04-04T19:59:37Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 1114
Last Update: 2024-04-29T07:50:56Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 794
Last Update: 2024-05-11T14:40:11Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 7787
Last Update: 2024-03-23T11:38:00Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 981
Last Update: 2023-12-20T20:10:23Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 228
Last Update: 2024-05-10T03:11:28Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 24526
Last Update: 2023-12-20T19:22:11Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 934
Last Update: 2024-05-10T21:33:44Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 3711
Last Update: 2023-11-30T07:55:19Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 814
Last Update: 2024-03-10T21:35:17Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 3024
Last Update: 2023-12-31T00:26:20Z
Anastrozole L02BG04 Letrozole L02BG05 Vorozole L02BG06 Exemestane L02BX01 Abarelix L02BX02 Degarelix L02BX03 Abiraterone L02BX04 Relugolix L02BX53 Abiraterone...
Word Count : 239
Last Update: 2024-02-07T17:41:04Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 11654
Last Update: 2023-10-25T12:20:21Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 616
Last Update: 2024-04-02T04:25:40Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 3632
Last Update: 2023-09-18T18:23:21Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 254
Last Update: 2024-03-24T06:38:25Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 974
Last Update: 2023-12-20T19:52:50Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 785
Last Update: 2024-01-28T19:45:39Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 654
Last Update: 2024-01-23T20:52:42Z
Leuprorelin (leuprolide) Nafarelin Peforelin Triptorelin Antagonists Peptide: Abarelix Cetrorelix Degarelix Ganirelix Non-peptide: Elagolix Linzagolix† Relugolix...
Word Count : 2100