Cartoon structure of a human galactokinase 1 monomer in complex with galactose (red) and an ATP analogue (orange). A magnesium ion is visible as a green sphere. (From PDB: 1WUU)
Identifiers
Symbol
GALK1
Alt. symbols
GALK
NCBI gene
2584
HGNC
4118
OMIM
604313
RefSeq
NM_000154
UniProt
P51570
Other data
EC number
2.7.1.6
Locus
Chr. 17 q23-q25
Search for
Structures
Swiss-model
Domains
InterPro
Galactokinase 2
Identifiers
Symbol
GALK2
NCBI gene
2585
HGNC
4119
OMIM
137028
RefSeq
NM_002044
UniProt
Q01415
Other data
EC number
2.7.1.6
Locus
Chr. 15 [1]
Search for
Structures
Swiss-model
Domains
InterPro
Galactokinase is an enzyme (phosphotransferase) that facilitates the phosphorylation of α-D-galactose to galactose 1-phosphate at the expense of one molecule of ATP.[1] Galactokinase catalyzes the second step of the Leloir pathway, a metabolic pathway found in most organisms for the catabolism of α-D-galactose to glucose 1-phosphate.[2] First isolated from mammalian liver, galactokinase has been studied extensively in yeast,[3][4] archaea,[5] plants,[6][7] and humans.[8][9]
^"galactokinase". Medical Dictionary. Retrieved 2013-01-26.
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^Hartley A, Glynn SE, Barynin V, Baker PJ, Sedelnikova SE, Verhees C, de Geus D, van der Oost J, Timson DJ, Reece RJ, Rice DW (March 2004). "Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase". Journal of Molecular Biology. 337 (2): 387–98. doi:10.1016/j.jmb.2004.01.043. PMID 15003454.
^Foglietti MJ, Percheron F (1976). "[Purification and mechanism of action of a plant galactokinase]". Biochimie. 58 (5): 499–504. doi:10.1016/s0300-9084(76)80218-0. PMID 182286.
^Dey PM (October 1983). "Galactokinase of Vicia faba seeds". European Journal of Biochemistry. 136 (1): 155–9. doi:10.1111/j.1432-1033.1983.tb07720.x. PMID 6617655.
^Holden HM, Thoden JB, Timson DJ, Reece RJ (October 2004). "Galactokinase: structure, function and role in type II galactosemia". Cellular and Molecular Life Sciences. 61 (19–20): 2471–84. doi:10.1007/s00018-004-4160-6. PMID 15526155. S2CID 7293337.
^Cite error: The named reference meg was invoked but never defined (see the help page).
Galactokinase is an enzyme (phosphotransferase) that facilitates the phosphorylation of α-D-galactose to galactose 1-phosphate at the expense of one molecule...
Galactokinase deficiency is an autosomal recessive metabolic disorder marked by an accumulation of galactose and galactitol secondary to the decreased...
galactosemia, the enzymes needed for further metabolism of galactose (Galactokinase and galactose-1-phosphate uridyltransferase) are severely diminished...
product of galactose. It has a slightly sweet taste. In people with galactokinase deficiency, a form of galactosemia, excess dulcitol forms in the lens...
pathway. The enzymes are listed in the order of the metabolic pathway: galactokinase (GALK), galactose-1-phosphate uridyltransferase (GALT), and UDP-galactose-4’-epimerase...
main classes of enzymes). Another example is the conversion of a yeast galactokinase (Gal1) to a transcription factor (Gal3) which can be achieved by an...
glucose, galactose travels to the liver for conversion to glucose. Galactokinase uses one molecule of ATP to phosphorylate galactose. The phosphorylated...
galactose are phosphorylated in the liver by fructokinase (Km= 0.5 mM) and galactokinase (Km = 0.8 mM), respectively. By contrast, glucose tends to pass through...
active form in the pathway. Next, α-D-galactose is phosphorylated by galactokinase to galactose 1-phosphate. In the third step, D-galactose-1-phosphate...
Iditol is a sugar alcohol which accumulates in galactokinase deficiency.[citation needed] Idose Aldose reductase L-iditol 2-dehydrogenase "2-Carb-19"...
Name Enzyme Description galactokinase deficiency Galactokinase Causes cataracts, which form due to the elevation of galactitol that accumulates when galactose...
function on different protein folds: The hexokinase, ribokinase, and galactokinase families of sugar kinases". Protein Science. 2 (1): 31–40. doi:10.1002/pro...
and activates them. In yeast cells, the principal targets are GAL1 (galactokinase), GAL10 (UDP-glucose 4-epimerase), and GAL7 (galactose-1-phosphate...
reduction product of galactose Iditol, a sugar alcohol which accumulates in galactokinase deficiency Mannitol, a sugar alcohol used as a sweetener and medication...
enzymes. Members of this family include homoserine kinases EC 2.7.1.39, galactokinases EC 2.7.1.6, and mevalonate kinasesEC 2.7.1.36. These kinases make up...
function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases". Protein Science. 2 (1): 31–40. doi:10.1002/pro...
hydrolyzed, D-Galactose enters the liver via the bloodstream. There, galactokinase phosphorylates it to galactose-1-phosphate using ATP. This compound...
less severe than classic galactosemia and is caused by a deficiency of galactokinase. Galactosemia renders infants unable to process the sugars in breast...
of cataract among classic galactosemics is markedly less than among galactokinase-deficient patients due to the extremely high levels of galactitol found...
binding sites to transport oxygen. The hexokinase, ribokinase, and galactokinase families of sugar kinases have similar enzymatic functions of sugar...
GALK2 may refer to: N-acetylgalactosamine kinase, an enzyme Galactokinase, an enzyme This disambiguation page lists articles associated with the same...
missense mutation in exon 6. A milder form of galactosemia, called Galactokinase deficiency, is caused a lack of the enzyme uridine diphosphate galactose-4-epimerase...
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