The Leloir pathway is a metabolic pathway for the catabolism of D-galactose. It is named after Luis Federico Leloir, who first described it.[1][2][3][4]
Intermediates and enzymes in the Leloir pathway of galactose metabolism[5]
In the first step, galactose mutarotase facilitates the conversion of β-D-galactose to α-D-galactose since this is the active form in the pathway. Next, α-D-galactose is phosphorylated by galactokinase to galactose 1-phosphate. In the third step, D-galactose-1-phosphate uridylyltransferase converts galactose 1-phosphate to UDP-galactose using UDP-glucose as the uridine diphosphate source. Finally, UDP-galactose 4-epimerase recycles the UDP-galactose to UDP-glucose for the transferase reaction. Additionally, phosphoglucomutase converts the D-glucose 1-phosphate to D-glucose 6-phosphate.[6]
^Caputto, R; Leloir, L.F.; Trucco, R.E.; Cardini, C.E.; Paladini, A C (1949). "The enzymatic transformation of galactose into glucose derivatives". J. Biol. Chem. 179 (1): 497–498. doi:10.1016/S0021-9258(18)56863-0. hdl:11336/135761. PMID 18119268.
^Cardini, C. E.; Paladini, A. C.; Caputto, R.; Leloir, L. F. (1950). "Uridine Diphosphate Glucose: The Coenzyme of the Galactose–Glucose Phosphate Isomerization". Nature. 165 (4188): 191–192. Bibcode:1950Natur.165..191C. doi:10.1038/165191a0. hdl:11336/140707. S2CID 44975916.
^Leloir, Luis F. (1951). "The enzymatic transformation of uridine diphosphate glucose into a galactose derivative". Archives of Biochemistry and Biophysics. 33 (2): 186–190. doi:10.1016/0003-9861(51)90096-3. hdl:11336/140700. PMID 14885999.
^Cite error: The named reference Leloir was invoked but never defined (see the help page).
^Cite error: The named reference Frey1996 was invoked but never defined (see the help page).
The Leloirpathway is a metabolic pathway for the catabolism of D-galactose. It is named after Luis Federico Leloir, who first described it. In the first...
of the metabolic pathways by which carbohydrates are synthesized and converted into energy in the body. Although born in France, Leloir received the majority...
the Leloirpathway; humans and other species, however, have been noted to contain several alternate pathways, such as the De Ley Doudoroff Pathway. The...
molecule of ATP. Galactokinase catalyzes the second step of the Leloirpathway, a metabolic pathway found in most organisms for the catabolism of α-D-galactose...
α-aldose to the β-anomer. This enzyme catalyzes the first step of the Leloirpathway, which is involved in galactose metabolism. It belongs to family of...
converted into glucose by the action of three enzymes, known as the Leloirpathway. There are diseases associated with deficiencies of each of these three...
catabolism of galactose. In the liver, galactose is converted through the Leloirpathway to glucose 6-phosphate in the following reactions: galacto- uridyl phosphogluco-...
glucokinase. Another hormone that may affect lipogenesis through the SREBP-1 pathway is leptin. It is involved in the process by limiting fat storage through...
by PC is an important intermediate, which is used in these biosynthetic pathways. In mammals, PC is expressed in a tissue-specific manner, with its activity...
Thoden, James B. (2003-11-07). "Structure and function of enzymes of the Leloirpathway for galactose metabolism". The Journal of Biological Chemistry. 278...
hepatitis is depletion of the energy source of hepatocytes. In the Leloirpathway galactosamine is metabolized into galactosamine-1-phosphate (by galactokinase)...
variant galactosemia) Leloir metabolic pathway: Galactose-1Puridylyltransferase (GALT, red font) is the middle enzyme in the Leloirpathway of galactose metabolism...
earned him the 1970 Nobel Prize in Physiology. This became known as “Leloir'spathway” and was a significant advance for biochemistry. As a consequence of...
Galactokinase catalyzes the first step of galactose phosphorylation in the Leloirpathway of intermediate metabolism. Galactokinase deficiency is one of the three...
glycolysis. It is derived from galactose an epimer of glucose, and via the LeloirPathway, it is used be used as a precursor for the metabolism of glucose into...
Type III galactosemia. Blockage of the Leloirpathway by GALE deficiency or dysfunction activates alternate pathways of glucose metabolism and leads to galactitol...
Burlington: Elsevier. ISBN 978-0-08-053789-4. Retrieved 25 June 2014. Cabib, E.; Leloir, L. F. (1958). "The biosynthesis of trehalose phosphate". The Journal of...
glucose) received the Nobel Prize in Physiology or Medicine. In 1970, Luis Leloir was awarded the Nobel Prize in Chemistry for the discovery of glucose-derived...
(1): 110–116. doi:10.1016/0005-2736(91)90110-t. PMID 1932043. Parodi AJ, Leloir LF (April 1979). "The role of lipid intermediates in the glycosylation of...
pp. 179–182. doi:10.1016/0076-6879(66)08028-5. ISBN 978-0-12-181808-1. LELOIR LF, CARDINI CE (1956). "Enzymes acting on glucosamine phosphate". Biochim...
Montemurro Lab at the University of Bari Aldo Moro. The Yanovsky Lab at the Leloir Institute. At the forefront of the field, plants were used as models to...
Chemistry 1987 Collège de France Louis Pasteur University Luis Federico Leloir Chemistry 1970 University of Buenos Aires Philipp Lenard Physics 1905 University...
Federico Leloir and collaborated with him on ketogenesis. Edson dedicated his 1966 paper on glucogenesis from sorbitol to LeLoir to celebrate Leloir's 60th...
at UBA. Luis Federico Leloir, Argentina's first Nobel Prize in Chemistry laureate for his discovery of the metabolic pathways in lactose, earned his...
hence, the role of nucleotide sugars - was not clear until the 1950s when Leloir and his coworkers found that the key enzymes in this process are the glycosyltransferases...
Global Information