GABA transporter 1 (GAT1) also known as sodium- and chloride-dependent GABA transporter 1 is a protein that in humans is encoded by the SLC6A1 gene and belongs to the solute carrier 6 (SLC6) family of transporters.[5][6][7] It mediates gamma-aminobutyric acid's translocation from the extracellular to intracellular spaces within brain tissue and the central nervous system as a whole.[8][9]
^ abcGRCh38: Ensembl release 89: ENSG00000157103 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030310 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Huang F, Shi LJ, Heng HH, Fei J, Guo LH (September 1995). "Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25". Genomics. 29 (1): 302–304. doi:10.1006/geno.1995.1253. PMID 8530094.
^"Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1".
^Scimemi A (2014). "Structure, function, and plasticity of GABA transporters". Frontiers in Cellular Neuroscience. 8: 161. doi:10.3389/fncel.2014.00161. PMC 4060055. PMID 24987330.
^Gonzalez-Burgos G (2010). "GABA transporter GAT1: a crucial determinant of GABAB receptor activation in cortical circuits?". GABABReceptor Pharmacology - A Tribute to Norman Bowery. Advances in Pharmacology. Vol. 58. pp. 175–204. doi:10.1016/S1054-3589(10)58008-6. ISBN 9780123786470. PMID 20655483.
^Johannesen KM, Gardella E, Linnankivi T, Courage C, de Saint Martin A, Lehesjoki AE, et al. (February 2018). "Defining the phenotypic spectrum of SLC6A1 mutations". Epilepsia. 59 (2): 389–402. doi:10.1111/epi.13986. PMC 5912688. PMID 29315614.
and 30 Related for: GABA transporter type 1 information
The GABAtransporter group consists of six different transporters: GABAtransportertype1 (GAT1; SLC6A1) GABAtransportertype 2 (GAT2; SLC6A13) GABA transporter...
GABAtransportertype 3 (GAT3) uses sodium (Na+) electrochemical gradients to mediate uptake of GABA from the synaptic cleft by surrounding glial cells...
GABAtransporter 2 (GAT2; SLC6A13) also known as sodium- and chloride-dependent GABAtransporter 2 is one of four GABAtransporters, GAT1 (SLC6A1), GAT2...
channels and components of the GABA system, their targets include GABAA receptors, the GABAtransportertype1, and GABA transaminase. Additional targets...
of the gamma-Aminobutyric acid transporters (GATs). This in turn leads to increased extracellular concentrations of GABA and therefore an increase in GABAergic...
NKCC1 co-transporters relative to KCC2 co-transporters in immature cells. GABAergic interneurons mature faster in the hippocampus and the GABA machinery...
(GABA vesicular transporter), member 1". McIntire SL, Reimer RJ, Schuske K, et al. (1997). "Identification and characterization of the vesicular GABA transporter"...
decarboxylase (GAD), GABAtransporters (GAT) and promote GABA metabolism. This leads to the reduced expression of extracellular GABA expression, inhibited...
A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other...
carrier family 18 member 2 (SLC18A2) also known as vesicular monoamine transporter 2 (VMAT2) is a protein that in humans is encoded by the SLC18A2 gene...
sodium/chloride-dependent family of neurotransmitter transporters, including dopamine, epinephrine, serotonin and GABAtransporters. A single-nucleotide polymorphism (SNP)...
upon hydrophobic sequence analysis and sequence similarities with the GABAtransporter. These methods predicted twelve transmembrane domains (TMD) with a...
decrease in either glutamate or GABA release. Limiting glutamate release causes reduced excitation, while limiting GABA release suppresses inhibition,...
ligand-gated ion channel. Its endogenous ligand is γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Accurate...
Reuptake inhibitors (RIs) are a type of reuptake modulators. It is a drug that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter...
A GABA analogue is a compound which is an analogue or derivative of the neurotransmitter gamma-Aminobutyric acid (GABA) (the IUPAC of which is 4-aminobutanoic...
glutamine and GABAtransporters. Succinate may thus be produced from enhanced glutamine metabolism via alpha-ketoglutarate or the GABA shunt.[citation...
Monoamine transporters (MATs) are proteins that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine...
inhibitor (GRI) is a type of drug which inhibits the reuptake of the neurotransmitter glycine by blocking one or more of the glycine transporters (GlyTs). Examples...
acid transporter Vesicular inhibitory amino acid transporter (VIAAT) is responsible for the storage of GABA and glycine in neuronal synaptic vesicles. SLC32A1;...
cysteine string protein (CSP) and vesicular GABAtransporter VGAT, which, as a complex, helps package GABA into vesicles for release during neurotransmission...
cleft. The SLC6A1 gene encodes GABA transporters. The transporters are electrogenic and couples 2 Na+, 1 Cl− and 1GABA for inward translocation. K+Cl− Symporter...
localization of glycine and GABA receptors. Deficiencies in collybistin function would result in a lack of glycine and GABA receptors at the synaptic cleft...
different types of transporters including pumps, uniporters, antiporters, and symporters. Active transporters or ion pumps are transporters that convert...
isoform of the GABA membrane transporter, GAT-1, and this serves as their identifying feature. GAT-1 is involved in the process of GABA reuptake into nerve...
GAT2 may refer to certain proteins: GABAtransportertype 2 BGT-1, sometimes also referred to as GAT2 This disambiguation page lists articles associated...
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