Cannabinoid receptor 1 (CB1), is a G protein-coupled cannabinoid receptor that in humans is encoded by the CNR1 gene.[5] The human CB1 receptor is expressed in the peripheral nervous system and central nervous system.[5] It is activated by endogenous cannabinoids[6] called endocannabinoids, a group of retrograde neurotransmitters that include lipids, such as anandamide and 2-arachidonoylglycerol (2-AG); plant phytocannabinoids, such as docosatetraenoylethanolamide found in wild daga, the compound THC which is an active constituent of the psychoactive drug cannabis; and synthetic analogs of THC. CB1 is antagonized by the phytocannabinoid tetrahydrocannabivarin (THCV).[7][8]
The primary endogenous agonist of the human CB1 receptor is anandamide.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000118432 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000044288 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcAbood M, Barth F, Bonner TI, Cabral G, Casellas P, Cravatt BF, et al. (22 August 2018). "CB1 Receptor". IUPHAR/BPS Guide to Pharmacology. International Union of Basic and Clinical Pharmacology. Retrieved 9 November 2018.
^Busquets Garcia A, Soria-Gomez E, Bellocchio L, Marsicano G (24 May 2016). "Cannabinoid receptor type-1: breaking the dogmas". F1000Research. 5: 990. doi:10.12688/f1000research.8245.1. PMC 4879932. PMID 27239293.
^Thomas A, Stevenson LA, Wease KN, Price MR, Baillie G, Ross RA, et al. (December 2005). "Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist". British Journal of Pharmacology. 146 (7): 917–926. doi:10.1038/sj.bjp.0706414. PMC 1751228. PMID 16205722.
^Pertwee RG, Thomas A, Stevenson LA, Ross RA, Varvel SA, Lichtman AH, et al. (March 2007). "The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo". British Journal of Pharmacology. 150 (5): 586–594. doi:10.1038/sj.bjp.0707124. PMC 2189766. PMID 17245367.
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animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol...
appetite-regulating peptide hormones leptin and ghrelin, among others. Notably, cannabinoidreceptor1 (CB1) is colocalized on orexinergic projection neurons in the lateral...
dose-dependent buildup of cannabinoids and related effects of cannabinoid toxicity the functionality of cannabinoidreceptors in the brain and particularly...
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To exert the psychoactive effect, specific receptors such as cannabinoid, dopamine and serotonin receptors are either stimulated or inhibited There are...
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