Fibronectin binding protein A (FnBPA) is a Staphylococcus aureus[1] MSCRAMM cell surface-bound protein that binds to both fibronectin and fibrinogen.
It is an adhesin which enables Staphylococcus aureus (S. aureus) to adhere to host cells of another organism, and an invasin facilitating its internalisation into these cells.[2] This is true over a range of different cell types.[2][3][4] The FnBP alone is capable of providing this invasive property, without the requirement of co-receptors. Even FnBP coated beads have been shown to become internalised into cells[2]
S. aureus is able to bind to host cells in the absence of the FnBP, but its adherence and invasive properties are much reduced (up to a 500-fold decrease in number of internalised cells)[2]
^Jönsson K, Signäs C, Müller HP, Lindberg M (December 1991). "Two different genes encode fibronectin binding proteins in Staphylococcus aureus. The complete nucleotide sequence and characterization of the second gene". European Journal of Biochemistry. 202 (3): 1041–8. doi:10.1111/j.1432-1033.1991.tb16468.x. PMID 1837266.
^ abcdSinha B, Francois P, Que YA, Hussain M, Heilmann C, Moreillon P, Lew D, Krause KH, Peters G, Herrmann M (2000). "Heterologously Expressed Staphylococcus aureus Fibronectin-Binding Proteins Are Sufficient for Invasion of Host Cells". Infect. Immun. 68 (12): 6871–8. doi:10.1128/iai.68.12.6871-6878.2000. PMC 97792. PMID 11083807.
^Jett BD, Gilmore MS (2002). "Internalization of Staphylococcus aureus by Human Corneal Epithelial Cells: Role of Bacterial Fibronectin-Binding Protein and Host Cell Factors". Infect. Immun. 70 (8): 4697–700. doi:10.1128/iai.70.8.4697-4700.2002. PMC 128182. PMID 12117986.
^Ahmed S, Meghji S, Williams RJ, Henderson B, Brock JH, Nair SP (2001). "Staphylococcus aureus Fibronectin Binding Proteins Are Essential for Internalization by Osteoblasts but Do Not Account for Differences in Intracellular Levels of Bacteria". Infect. Immun. 69 (5): 2872–7. doi:10.1128/IAI.69.5.2872-2877.2001. PMC 98237. PMID 11292701.
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