Fibrinogen beta chain, also known as FGB, is a gene found in humans and most other vertebrates with a similar system of blood coagulation.
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000171564 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000033831 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: FGB fibrinogen beta chain".
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the integrin betachainbeta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a betachain. A given chain may combine with...
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on some serotypes is also able to prevent opsonization by binding to fibrinogen. However, the M protein is also the weakest point in this pathogen's defense...
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clotting of blood. It is formed by the action of the protease thrombin on fibrinogen, which causes it to polymerize. The polymerized fibrin, together with...
or no classical amyloid fibrils, such as the diffuse deposits of amyloid beta (Aβ) protein in the brains of people with Alzheimer's. Furthermore, evidence...
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integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a betachain. This protein combines...
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enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different...
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environmental factors. The four most common types of systemic amyloidosis are light chain (AL), inflammation (AA), dialysis-related (Aβ2M), and hereditary and old...
"On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proc. Soc. Exp. Biol. Med. 208 (4): 346–60. PMID 7535429...
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Trypanosoma parasite Tubulin Some clotting factors Factor XI Factor XIII Fibrinogen Some receptors Nuclear receptors G protein βγ-subunit dimer Toll-like...
variation, found by Eric Brunner (epidemiologist) of UCL; Sir Richard Way; fibrinogen variation, found by Prof Sam Machin, haematologist at University College...
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