Fibrin glue applied after drying the scleral bed in an intraocular lens operation
Combination of
Fibrinogen
Glycoprotein
Thrombin
Coagulation factor
Clinical data
Trade names
Artiss, Evicel, Tisseel, others
AHFS/Drugs.com
Professional Drug Facts
License data
US DailyMed: Evicel
Pregnancy category
AU: B2[1][2]
Routes of administration
Topical
ATC code
B02BC30 (WHO)
Legal status
Legal status
AU: S4 (Prescription only)[1][3]
CA: ℞-only /Schedule D[4]
UK: POM (Prescription only)[5][6][7]
US: ℞-only
EU: Rx-only
In general: ℞ (Prescription only)
Identifiers
CAS Number
9001-32-5
9002-04-4
DrugBank
DB09222
DB11571
UNII
N94833051K
6K15ABL77G
Fibrin glue (also called fibrin sealant) is a surgical formulation used to create a fibrin clot for hemostasis, cartilage repair surgeries or wound healing. It contains separately packaged human fibrinogen and human thrombin.[8][9][10][11][12][13][14][15][16][17]
^ ab"VeraSeal". Therapeutic Goods Administration (TGA). 12 November 2021. Retrieved 28 December 2021.
^"Updates to the Prescribing Medicines in Pregnancy database". Therapeutic Goods Administration (TGA). 12 May 2022. Retrieved 13 May 2022.
^"AusPAR: Human Fibrinogen / Human Thrombin". Therapeutic Goods Administration (TGA). 29 June 2022. Retrieved 17 July 2022.
^"Health product highlights 2021: Annexes of products approved in 2021". Health Canada. 3 August 2022. Retrieved 25 March 2024.
^"TachoSil sealant matrix - Summary of Product Characteristics (SmPC)". (emc). 31 January 2020. Archived from the original on 10 July 2020. Retrieved 10 July 2020.
^"Tisseel Ready to use Solutions for Sealant - Summary of Product Characteristics (SmPC)". (emc). 30 December 2019. Retrieved 10 July 2020.
^"Artiss Solutions for Sealant - Summary of Product Characteristics (SmPC)". (emc). 29 January 2019. Retrieved 10 July 2020.
^Irwin RM, Bonassar LJ, Cohen I, Matuska AM, Commins J, Cole B, Fortier LA (8 November 2019). "The clot thickens: Autologous and allogeneic fibrin sealants are mechanically equivalent in an ex vivo model of cartilage repair". PLOS ONE. 14 (11): e0224756. Bibcode:2019PLoSO..1424756I. doi:10.1371/journal.pone.0224756. PMC 6839864. PMID 31703078.
^Shah NV, Meislin R (December 2013). "Current state and use of biological adhesives in orthopedic surgery". Orthopedics. 36 (12): 945–956. doi:10.3928/01477447-20131120-09. PMID 24579215.
^Smith BL, Matuska AM, Greenwood VL, Gilat R, Wijdicks CA, Cole BJ (15 April 2022). "Autologous Fibrin Sealants Have Comparable Graft Fixation to an Allogeneic Sealant in a Biomechanical Cadaveric Model of Chondral Defect Repair". Arthroscopy, Sports Medicine, and Rehabilitation. 4 (3): e1075–e1082. doi:10.1016/j.asmr.2022.03.003. ISSN 2666-061X. PMC 9210474. PMID 35747626. S2CID 248208731.
^Shinohara K, Kobayashi E, Yoshida T, Toyama N, Kiyozaki H, Fujimura A, Miyata M (1998). "Effect of fibrin glue on small and large bowel anastomoses in the rat". European Surgical Research. 30 (1): 8–12. doi:10.1159/000008552. PMID 9493689. S2CID 46792418.
^Spotnitz WD, Mintz PD, Avery N, Bithell TC, Kaul S, Nolan SP (August 1987). "Fibrin glue from stored human plasma. An inexpensive and efficient method for local blood bank preparation". The American Surgeon. 53 (8): 460–462. PMID 2440358.
^Saxena S, Jain P, Shukla J (2003). "Preparation of two component Fibrin Glue and its clinical evaluation in skin grafts and flaps". Indian J Plast Surg. 36 (1): 14–17.
^Mücke T, Wolff KD (2009). "Performing microvascular anastomosis with fibrin glue--faster, easier, and more reliable?". Microsurgery. 29 (1): 80–81. doi:10.1002/micr.20556. PMID 18946885. S2CID 31854904.
Fibringlue (also called fibrin sealant) is a surgical formulation used to create a fibrin clot for hemostasis, cartilage repair surgeries or wound healing...
See adhesive for general discussion of glue. This is a list of various types of glue. Historically, the term "glue" only referred to protein colloids prepared...
following an anterior chamber IOL, or subluxated or dislocated IOL. Fibringlue has been used previously, in various medical specialties, as a hemostatic...
an injection of the patient's own blood at the site of the leak, a fibringlue injection, or surgery. A spontaneous CSF leak is a rare condition, affecting...
as in traumatic bleeding secondary to gunshot wounds). Thrombin and fibringlue are used surgically to treat bleeding and to thrombose aneurysms. Hemostatic...
thrombin which participate in blood clotting. Fibringlue or fibrin sealant is also referred to as a fibrin based scaffold and used to control surgical...
fibringlue). Il Dentista Moderno, 9, 57-70. Italy Petti G. (1988) “A new attachment:guided tissue regeneration using an amniotic membrane and fibrin...
of tissue adhesive fibringlue. A Cochrane review including 14 studies and last updated October 2016, found that using fibringlue when doing conjunctival...
antibiotic therapy. In some cases the fistula is temporarily covered using a fibringlue or plug. A catheter may be required to drain a fistula. Globally, every...
trauma or childbirth. Current treatment options include CSF aspiration, fibrin-glue therapy, laminectomy with wrapping of the cyst, among other surgical...
randomised trials. Another technique is to treat pilonidal sinus with fibringlue. This technique is of unclear benefit as of 2017 due to insufficient...
erythromycin, vancomycin as well as other agents like ethanol, talc, and fibringlue. Promoting adhesion with sclerosing agents can also prevent fluid from...
closed with fibringlue. In the IOL scaffold, the IOL is placed above the iris or above some remnant of the capsule. Otherwise, a glued IOL then acts...
less frequently, this may be permanent. Some people may benefit from fibringlue mixed with the blood. EBP may cause more side effects than a topical...
time, using micro surgical technique, the anastomosis is completed and fibringlue is applied to the anastomotic suture line to help prevent leakage and...
healing Fibringlue injection is a method explored in recent years, with variable success. It involves injecting the fistula with a biodegradable glue which...
into the epidural space (an epidural blood patch), spinal surgery, or fibringlue. CSF can be tested for the diagnosis of a variety of neurological diseases...
including: epinephrine injection, band ligation, sclerotherapy, and fibringlue depending on what is found. Prokinetic agents such as erythromycin before...
anaesthesia for intractable salivary aspiration: cricoidectomy with fibringlue support" The Journal of Laryngology & Otology:Cambridge University Press...
measures, such as the use of oxidized cellulose, for example, Surgicel or fibringlue in conjunction with post-operatively administered antifibrinolytic agents...
the resulting clots are then harvested, and then dissolved, forming a fibringlue that is then used on the person during the surgery. Gottlieb Z (3 November...
no way to tell this reconstituted meat from real meat". Cerastocytin Fibringlue Fibrinogen PA clan of proteases The Proteolysis Map Thrombin generation...
Global Information