negative regulation of endothelial cell apoptotic process
positive regulation of peptide hormone secretion
protein polymerization
positive regulation of heterotypic cell-cell adhesion
fibrinolysis
platelet degranulation
blood coagulation
extracellular matrix organization
protein secretion
response to calcium ion
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of vasoconstriction
positive regulation of protein secretion
positive regulation of ERK1 and ERK2 cascade
positive regulation of exocytosis
blood coagulation, fibrin clot formation
plasminogen activation
cell-matrix adhesion
platelet aggregation
signal transduction
platelet activation
toll-like receptor signaling pathway
platelet maturation
cellular response to interleukin-1
cellular response to interleukin-6
negative regulation of platelet aggregation
post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2266
99571
Ensembl
ENSG00000171557
ENSMUSG00000033860
UniProt
P02679
Q8VCM7
RefSeq (mRNA)
NM_021870 NM_000509
NM_133862 NM_001317105
RefSeq (protein)
NP_000500 NP_068656
NP_001304034 NP_598623
Location (UCSC)
Chr 4: 154.6 – 154.61 Mb
Chr 3: 82.92 – 82.92 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Fibrinogen gamma chain, also known as fibrinogen gamma gene (FGG), is a human gene found on chromosome 3.[5]
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.[6] Alternative splicing of the mRNA chain results in two transcript variants; the common γA chain and the alternatively spliced γ' chain. Approximately 10% of the total plasma fibrinogen consists of γA/γ' fibrinogen, with <1% consisting of γ'/γ' fibrinogen. Increased and decreased levels of γA/γ' fibrinogen have been associated with coronary artery disease and deep vein thrombosis respectively.
In the lung parenchyma of smokers, upregulation of FGG transcript levels has been reported. [7]
^ abcGRCh38: Ensembl release 89: ENSG00000171557 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000033860 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Emeis J (2007). "A guide to murine coagulation factor structure, function, assays, and genetic alterations". Journal of Thrombosis and Haemostasis. 5 (4): 670–679. doi:10.1111/j.1538-7836.2007.02408.x. PMID 17403201.
^"Entrez Gene: FGG fibrinogen gamma chain".
^Pintarelli G, Noci S, Maspero D, Pettinicchio A, Dugo M, De Cecco L, Incarbone M, Tosi D, Santambrogio L, Dragani TA, Colombo F (September 2019). "Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients". Scientific Reports. 9 (1): 13039. Bibcode:2019NatSR...913039P. doi:10.1038/s41598-019-49648-2. PMC 6736939. PMID 31506599.
and 26 Related for: Fibrinogen gamma chain information
Fibrinogengammachain, also known as fibrinogengamma gene (FGG), is a human gene found on chromosome 3. The protein encoded by this gene is the gamma...
the Bβ or β chain) encoded by the FGB gene, and the fibrinogengammachain (also termed the γ chain) encoded by the FGG gene. All three genes are located...
the carboxy-terminus. Fibrinogen alpha chain has been shown to interact with tissue plasminogen activator. Fibrinogengammachain GRCh38: Ensembl release...
the fibrinogen alpha chain gene (also termed the FGA gene), 5 in the fibrinogen beta chain gene (also termed the FGB gene), and 17 in the fibrinogen gamma...
thrombotic tendency. Fibrinogen beta chain has been shown to interact with Lipoprotein(a). Fibrin Fibrinogen alpha chainFibrinogengammachain GRCh38: Ensembl...
Greenwich Group, an American investment firm Federation of Gay Games Fibrinogengammachain Flat Glass Group, a Chinese glass production company Foundation...
blood-coagulation factor II, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, that converts fibrinogen into strands of insoluble fibrin, as well as...
improve the texture of protein-rich foods such as surimi or ham. Thrombin–fibrinogen "meat glue" from bovine and porcine sources was banned throughout the...
rheumatoid arthritis (increased IgA). Fibrinogen from plasma samples will be seen in the beta gamma region. Fibrinogen, a beta-2 protein, is found in normal...
formed after thrombin cleavage of fibrinopeptide A (FPA) from fibrinogen Aalpha-chains, thus initiating fibrin polymerization. Double-stranded fibrils...
immunoglobulin light chain amyloidosis (AL amyloidosis), chemotherapy can be used to lower the number of the blood cells that make the light chain protein that...
is similar to the β- and γ-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The...
factor XIIIa, and endothelial cell transglutaminase to human plasma fibrinogen, fibrin, and fibronectin". Mol. Cell. Biochem. 162 (1): 43–9. doi:10.1007/bf00250994...
C22orf15 more closely resembles the slope of the trendline for fibrinogen alpha chain, which evolves rapidly, as opposed to the slope of the trendline...
proteins involved in amyloid formation, including transthyretin (TTR), fibrinogen, apolipoprotein A1, or apolipoprotein A2. Due to the multiple number of...
fibrinogen, and coagulation factors V and XIII δ granules (delta or dense granules) – containing ADP or ATP, calcium, and serotonin γ granules (gamma...
occurring anticoagulant. Hementerin breaks the alpha (FGA), gamma (FGG) and beta (FGB) chains, by degrading cross-linked fibrin. It has no degrading action...
variation, found by Eric Brunner (epidemiologist) of UCL; Sir Richard Way; fibrinogen variation, found by Prof Sam Machin, haematologist at University College...
"Ceruloplasmin is a better predictor of the long-term prognosis compared with fibrinogen, CRP, and IL-6 in patients with severe unstable angina". Angiology. 60...
blood plasma. Its structure is that of a two-chain polypeptide consisting of a light chain and a heavy chain connected by a disulfide bond.: 4673 The protein...
factors F2 and F9, complement factor related proteins, and the fibrinogen beta chain protein. Organogenesis, the development of the organs, takes place...
Scarpellini MG, et al. (April 2004). "Absolute neutrophil counts and fibrinogen levels as an aid in the early diagnosis of acute myocardial infarction"...
for a Cetacea/Hippopotamidae clade: the blood-clotting protein gene gamma-fibrinogen". Molecular Biology and Evolution. 14 (5): 537–543. doi:10.1093/oxfordjournals...
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