Blood coagulation pathways in vivo showing the central role played by thrombin
Other names
TCT
MeSH
D013918
[edit on Wikidata]
The thrombin time (TT), also known as the thrombin clotting time (TCT), is a blood test that measures the time it takes for a clot to form in the plasma of a blood sample containing anticoagulant, after an excess of thrombin has been added.[1] It is used to diagnose blood coagulation disorders and to assess the effectiveness of fibrinolytic therapy. This test is repeated with pooled plasma from normal patients. The difference in time between the test and the 'normal' indicates an abnormality in the conversion of fibrinogen (a soluble protein) to fibrin, an insoluble protein.[2]
The thrombin time compares the rate of clot formation to that of a sample of normal pooled plasma. Thrombin is added to the samples of plasma. If the time it takes for the plasma to clot is prolonged, a quantitative (fibrinogen deficiency) or qualitative (dysfunctional fibrinogen) defect is present.[3] In blood samples containing heparin, a substance derived from snake venom called batroxobin[4] (formerly reptilase) is used instead of thrombin. Batroxobin has a similar action to thrombin but unlike thrombin it is not inhibited by heparin.[1]
Normal values for thrombin time are 12 to 14 seconds.[5] If batroxobin is used, the time should be between 15 and 20 seconds. Thrombin time can be prolonged by heparin, fibrin degradation products, and fibrinogen deficiency or abnormality.
^ abDavid Lillicrap; Nigel Key; Michael Makris; Denise O'Shaughnessy (2009). Practical Hemostasis and Thrombosis. Wiley-Blackwell. p. 53. ISBN 978-1-4051-8460-1.
^Popović M, Smiljanić K, Dobutović B, Syrovets T, Simmet T, Isenović ER (January 2012). "Thrombin and vascular inflammation". Molecular and Cellular Biochemistry. 359 (1–2): 301–13. doi:10.1007/s11010-011-1024-x. PMID 21858738. S2CID 14313728.
^Hatton, Chris (2008). Haematology (Lecture Notes). Cambridge, MA: Blackwell Publishers. p. 156. ISBN 978-1-4051-8050-4.
^Batroxobin factsheet
^Hoffbrand, A. V. (2002). Essential haematology. Oxford: Blackwell Science. p. 248. ISBN 978-0-632-05153-3.
The thrombintime (TT), also known as the thrombin clotting time (TCT), is a blood test that measures the time it takes for a clot to form in the plasma...
Organization. D-dimer Partial thromboplastin time (PTT), or activated partial thromboplastin time (aPTT or APTT) Thrombintime (TT) Thrombodynamics test Thromboelastography...
activity similar to thrombin. Unlike thrombin, reptilase is resistant to inhibition by antithrombin III. Thus, the reptilase time is not prolonged in...
"Short activated partial thromboplastin times are related to increased thrombin generation and an increased risk for thromboembolism". American Journal...
prothrombin time (PT), activated partial thromboplastin time (aPTT or PTT), activated clotting time (ACT), thrombintime (TT), or Reptilase time. These tests...
thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants (delaying blood clotting) by directly inhibiting the enzyme thrombin (factor...
the cause of prolongation of Prothrombin Time (PT), Partial Thromboplastin Time, or sometimes of thrombintime (TT). Mixing studies take advantage of the...
streaming from the eyes Tetanus toxoid, a vaccine to prevent tetanus Thrombintime, a coagulation blood test .tt, the country code top-level domain for...
thrombotic risk. It is based on the potential of a plasma to generate thrombin over time, following activation of coagulation via addition of phospholipids...
vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function...
which additives it contains. Blood collection tubes expire because over time the vacuum is lost and blood will not be drawn into the tube when the needle...
bleeding but a normal bleeding time, normal prothrombin time, normal thrombintime, but prolonged partial thromboplastin time. Internal bleeding is common...
fibrinogen assay for final common pathway (THROMBINTIME) Two other tests are regularly performed at the same time: blood count, to detect other hematological...
involved in the clotting of blood. It is formed by the action of the protease thrombin on fibrinogen, which causes it to polymerize. The polymerized fibrin, together...
chlorhexidine in 70% ethanol or isopropyl alcohol solution is preferred and time must be allowed for it to dry. The tops of any containers used when drawing...
activated partial thromboplastin time-APTT, prothrombin time with International Normalized Ratio-PTINR, thrombintime-TT, and fibrinogen level. Patients...
clot retraction test) as a replacement test for the more commonly used thrombintime. Because the enzyme is unaffected by heparin, it is mostly used when...
coagulation capability. The test is considered to be a replacement for thrombintime, and is used when heparin is present in the sample. The enzyme is unaffected...
the blood film), prothrombin time, partial thromboplastin time, thrombodynamics test, thrombintime and reptilase time, lupus anticoagulant, anti-cardiolipin...
quantitative and qualitative screening of fibrinogen is measured by the thrombin clotting time (TCT). Measurement of the exact amount of fibrinogen present in...
cases is <0.7. Partial thromboplastin time, activated partial thromboplastin time, thrombintime, and reptilase time tests are usually prolonged regardless...
minimally-invasive technique used today is ultrasound-guided thrombin injection. Thrombin (factor IIa in the coagulation cascade) is a clotting factor...
coagulation tests such as PT (prothrombin time), aPTT (activated partial thromboplastin time) or thrombintime are not very sensitive for hyperfibrinolysis...
Global Information