Hemochromatosis type 4 is a hereditary iron overload disorder that affects ferroportin, an iron transport protein needed to export iron from cells into circulation.[1] Although the disease is rare, it is found throughout the world and affects people from various ethnic groups. While the majority of individuals with type 4 hemochromatosis have a relatively mild form of the disease, some affected individuals have a more severe form. As the disease progresses, iron may accumulate in the tissues of affected individuals over time, potentially resulting in organ damage.[2]
^Roetto, A.; Camaschella, C. (2005). "New insights into iron homeostasis through the study of non-HFE hereditary haemochromatosis". Best Practice & Research Clinical Haematology. 18 (2): 235–250. doi:10.1016/j.beha.2004.09.004. PMID 15737887.
been identified in patients with type4hemochromatosis. The misregulation of ferroportin in type4hemochromatosis can involve a failure of ferroportin...
are five types of hereditary hemochromatosis: type 1, 2 (2A, 2B), 3, 4 and 5, all caused by mutated genes. Hereditary hemochromatosistype 1 is the most...
hereditary hemochromatosis", "non-HFE related hereditary hemochromatosis", or "non-HFE hemochromatosis". Most types of hereditary hemochromatosis have autosomal...
The following is a list of genetic disorders and if known, type of mutation and for the chromosome involved. Although the parlance "disease-causing gene"...
known to cause an autosomal dominant form of iron overload known as Hemochromatosistype4 or Ferroportin Disease. The effects of the mutations are generally...
diagnosed with type 3 hemochromatosis is TFR2 ( or HFE3). HFE (not the same as HFE3) is most often the cause of hereditary hemochromatosis. The HFE gene...
diagnosis of hereditary hemochromatosis, especially while serum ferritin still remains low. The retained iron in hereditary hemochromatosis is primarily deposited...
excessive iron absorption, as is the case with those with HFE hereditary hemochromatosis. Within the general population, 1 out of 400 people has the homozygous...
and mutations in this gene have been associated with hereditary hemochromatosistype III. Alternatively spliced variants which encode different protein...
hemochromatosis, and some cancer treatments. Broken heart syndrome is caused by extreme emotional or physical stress. Treatment depends on the type of...
into the cells of the body. Certain mutations in the HFE gene cause hemochromatosis (an iron overload disorder). People who have these mutations are also...
the iron overload condition known as juvenile hemochromatosis in humans, a severe form of hemochromatosis. In humans, the hemojuvelin protein is encoded...
overload are hereditary hemochromatosis (HH), caused by mutations in the HFE gene, and the more severe disease juvenile hemochromatosis (JH), caused by mutations...
high. Also called labile and unstable diabetes. Bronze diabetes See: Hemochromatosis. Bunion A bump or bulge on the first joint of the big toe caused by...
be carried out in the treatment of some blood disorders (example: Hemochromatosis, polycythemia vera, porphyria cutanea tarda), and chronic hives (in...
recessive, or X-linked dominant manner. One type, porphyria cutanea tarda, may also be due to hemochromatosis (increased iron in the liver), hepatitis C...
syndrome. Hereditary diseases that cause damage to the liver include hemochromatosis, involving accumulation of iron in the body, and Wilson's disease....
including Geritol, have been contraindicated because of concerns over hemochromatosis, and serious questions raised in studies for men, postmenopausal women...
function, genetic disorders such as Wilson's disease and hereditary hemochromatosis, and chronic heart failure with liver congestion. Diagnosis is based...
A hiatal hernia or hiatus hernia is a type of hernia in which abdominal organs (typically the stomach) slip through the diaphragm into the middle compartment...
gastritis (Type A gastritis) are statistically more likely to develop gastric carcinoma, Hashimoto's thyroiditis, and achlorhydria. Type A gastritis...
FTH1 gene is located on chromosome 11, and its mutation causes Hemochromatosistype 5. This gene encodes the heavy subunit of ferritin, the major intracellular...
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