Predicted secondary structure and sequence conservation of IRE
Identifiers
Symbol
IRE
Rfam
RF00037
Other data
RNA type
Cis-reg
Domain(s)
Eukaryota
SO
SO:0000233
PDB structures
PDBe
Crystal structure of iron regulatory protein 1 in complex with ferritin H IRE-RNA, Protein Data Bank entry 2IPY.[1]
In molecular biology, the iron response element or iron-responsive element (IRE) is a short conserved stem-loop which is bound by iron response proteins (IRPs, also named IRE-BP or IRBP). The IRE is found in UTRs (untranslated regions) of various mRNAs whose products are involved in iron metabolism. For example, the mRNA of ferritin (an iron storage protein) contains one IRE in its 5' UTR. When iron concentration is low, IRPs bind the IRE in the ferritin mRNA and cause reduced translation rates. In contrast, binding to multiple IREs in the 3' UTR of the transferrin receptor (involved in iron acquisition) leads to increased mRNA stability.
^William E. Walden; Anna I. Selezneva; Jerome Dupuy; Anne Volbeda; Juan C. Fontecilla-Camps; Elizabeth C. Theil & Karl Volz (December 2006). "Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA". Science. 314 (5807): 1903–1908. doi:10.1126/science.1133116. PMID 17185597. S2CID 26572367.
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