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Essential thrombocythemia information


Essential thrombocythemia
Other namesEssential thrombocythaemia, essential thrombocytosis, primary thrombocytosis
Histopathological image representing a bone marrow aspirate in a patient with essential thrombocythemia.
SpecialtyHematology Edit this on Wikidata
SymptomsFatigue, insomnia, migraines, headache, and dizziness.[1]
ComplicationsThrombosis, transient ischemic attack, acute coronary syndrome, Budd-Chiari syndrome.[1]
CausesOverproduction of hematopoietic cells, genetic mutations.[1]
Diagnostic methodClinical criteria.
Differential diagnosisChronic myelogenous leukemia, myelodysplastic syndrome, polycythemia vera, primary myelofibrosis, secondary thrombocytosis.[1]
TreatmentLow-dose aspirin, plateletpheresis, cytoreductive therapy.[1]
PrognosisMedian survival is 18 years.[1]
Frequency0.6-2.5/100,000 cases per year.[2]

In hematology, essential thrombocythemia (ET) is a rare chronic blood cancer (myeloproliferative neoplasm) characterised by the overproduction of platelets (thrombocytes) by megakaryocytes in the bone marrow.[3] It may, albeit rarely, develop into acute myeloid leukemia or myelofibrosis.[3] It is one of the blood cancers wherein the bone marrow produces too many white or red blood cells, or platelets.[3]

  1. ^ a b c d e f Ashorobi, Damilola; Gohari, Pouyan (August 6, 2023). Essential Thrombocytosis. Treasure Island (FL): StatPearls Publishing. PMID 30969531 – via PubMed.
  2. ^ Cite error: The named reference emerg was invoked but never defined (see the help page).
  3. ^ a b c Beer, PA; Green, AR (2009). "Pathogenesis and management of essential thrombocythemia". Hematology. 2009: 621–628. doi:10.1182/asheducation-2009.1.621. PMID 20008247.

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the cause is unknown, the term thrombocythemia is used, as either primary thrombocythemia or essential thrombocythemia. The condition arises from a fault...

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