Two megakaryocytes in bone marrow, marked with arrows.
Details
Location
Bone marrow
Function
Platelet production
Identifiers
Latin
megakaryocytus
MeSH
D008533
TH
H2.00.04.3.05003
FMA
83555
Anatomical terms of microanatomy
[edit on Wikidata]
A megakaryocyte (mega- + karyo- + -cyte, "large-nucleus cell") is a large bone marrow cell with a lobated nucleus that produces blood platelets (thrombocytes), which are necessary for normal clotting. In humans, megakaryocytes usually account for 1 out of 10,000 bone marrow cells, but can increase in number nearly 10-fold during the course of certain diseases.[1] Owing to variations in combining forms and spelling, synonyms include megalokaryocyte and megacaryocyte.
^Branehog I, Ridell B, Swolin B, Weinfeld A (1975). "Megakaryocyte quantifications in relation to thrombokinetics in primary thrombocythaemia and allied diseases". Scand. J. Haematol. 15 (5): 321–32. doi:10.1111/j.1600-0609.1975.tb01087.x. PMID 1060175.
A megakaryocyte (mega- + karyo- + -cyte, "large-nucleus cell") is a large bone marrow cell with a lobated nucleus that produces blood platelets (thrombocytes)...
Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene. Thrombopoietin...
expansion of hematopoietic stem cells, stimulating the increase of megakaryocyte progenitor cells, and supporting these cells so they mature to become...
former online music market CFU-GEMM, granulocyte-erythrocyte-monocyte-megakaryocyte colony forming unit Gem (disambiguation) This disambiguation page lists...
have no cell nucleus; they are fragments of cytoplasm derived from the megakaryocytes of the bone marrow or lung, which then enter the circulation. Platelets...
a precursor cell for a megakaryocyte. It arises from a megakaryoblast, into a promegakaryocyte and then into a megakaryocyte, which will eventually break...
lymphopoiesis. Cells of the myeloid lineage, which include granulocytes, megakaryocytes, monocytes, and macrophages, are derived from common myeloid progenitors...
Increased entry of megakaryocytes into the systemic circulation. Under normal circumstances in healthy individuals, megakaryocytes that arise from the...
production of blood cells such as erythrocytes (red cells), granulocytes and megakaryocytes, the latter cells responsible for the production of platelets. Signs...
features in platelet producing megakaryocytes (lack of lobation) Hypersegmented (osteoclastic appearing) megakaryocytes Ballooning of the platelets (seen...
macrophages, neutrophils, basophils, eosinophils, erythrocytes, and megakaryocytes to platelets. Lymphoid cells include T cells, B cells, natural killer...
glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF). Although it has been proposed that mesothelin...
characterised by the overproduction of platelets (thrombocytes) by megakaryocytes in the bone marrow. It may, albeit rarely, develop into acute myeloid...
thrombopoiesis, the promegakaryocyte matures into the form of a megakaryocyte. From the megakaryocyte, platelets are formed. The megakaryoblast is the beginning...
and entry into S-phase. The induction of endomitosis in mammalian megakaryocytes involves activation of the c-mpl receptor by the thrombopoietin (TPO)...
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with each round of replication and endomitosis. Platelet-producing megakaryocytes go through endomitosis during cell differentiation. Amitosis in ciliates...
the mast cell is not lobated. Lobation is also a characteristic of megakaryocytes in the bone marrow. Campbell, Neil A. (1996). Biology (4th ed.). Menlo...
be normal. Other common findings were megakaryocyte hyperplasia and clustering, as well as unusual megakaryocyte appearances. Atypical plasma cells invade...
proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production...
4-phosphate Mars Exploration Program, NASA Maximal expiratory pressure Megakaryocyte–erythroid progenitor cell Melanophlogite, a silicate mineral Motor evoked...
Assinger, A. (2018-02-20). "A novel method for automated assessment of megakaryocyte differentiation and proplatelet formation" (PDF). Platelets. 29 (4):...
used as a target for immunohistochemistry, where endothelial cells, megakaryocytes, platelets and mast cells normally stain positive. In the 1980s, some...
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