An endogenous viral element (EVE) is a DNA sequence derived from a virus, and present within the germline of a non-viral organism. EVEs may be entire viral genomes (proviruses), or fragments of viral genomes. They arise when a viral DNA sequence becomes integrated into the genome of a germ cell that goes on to produce a viable organism. The newly established EVE can be inherited from one generation to the next as an allele in the host species, and may even reach fixation.
Endogenous retroviruses and other EVEs that occur as proviruses can potentially remain capable of producing infectious virus in their endogenous state. Replication of such 'active' endogenous viruses can lead to the proliferation of viral insertions in the germline. For most non-retroviral viruses, germline integration appears to be a rare, anomalous event, and the resulting EVEs are often only fragments of the parent virus genome. Such fragments are usually not capable of producing infectious virus, but may express protein or RNA and even cell surface receptors.
and 26 Related for: Endogenous viral element information
the process of infecting a cell, viruses exist in the form of independent viral particles, or virions, consisting of (i) genetic material, i.e., long molecules...
longer periods of time as either inactive viral infections or an endogenousviralelement. In inactive viral infections the virus will not replicate itself...
Endogenous retroviruses (ERVs) are endogenousviral elements in the genome that closely resemble and can be derived from retroviruses. They are abundant...
A transposable element (TE, transposon, or jumping gene) is a nucleic acid sequence in DNA that can change its position within a genome, sometimes creating...
cancer Cosmid Defective interfering particle Endogenousviralelement Fosmid Integrative and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid...
cytoskeleton. The mitochondria-associated ER membrane (MAM) is another structural element that is increasingly recognized for its critical role in cellular physiology...
Viral vectors are modified viruses designed to deliver genetic material into cells. This process can be performed inside an organism or in cell culture...
these mobile genetic elements are found in angiosperms. Endogenousviralelement: These are viral nucleic acids integrated into the genome of a cell. They...
the cells start to degenerate shortly after they are infected, causing viral induction of apoptosis. HeLa cells have been used to study expression of...
the global viral community. Krupovic et al. (2018) states that the high levels of horizontal gene transfer, rapid mutation rates in viral genomes, and...
term plasmid should be adopted as the term for extrachromosomal genetic element, and to distinguish it from viruses, the definition was narrowed to genetic...
trophies or profits. Non-human animals are also an important cultural element of human evolution, having appeared in cave arts and totems since the earliest...
cancer Cosmid Defective interfering particle Endogenousviralelement Fosmid Integrative and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid...
A helper dependent virus, also termed a gutless virus, is a synthetic viral vector dependent on the assistance of a helper virus in order to replicate...
repair genes such as DMC1 may promote tumor cell growth by dealing with endogenous DNA damage within the tumor, and may also diminish the effectiveness of...
circa 5 kb in length. One of at least two open reading frames encodes a viral RNA-directed RNA polymerase, that firmly places "ambiviruses" into ribovirian...
RNA recognition motif (RRM). This primase is structurally similar to many viral RNA-dependent RNA polymerases, reverse transcriptases, cyclic nucleotide...
replicated as a plasmid, and also be packaged as single stranded DNA in viral particles. Phagemids contain an origin of replication (ori) for double stranded...
cancer Cosmid Defective interfering particle Endogenousviralelement Fosmid Integrative and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid...
uses recombination-dependent initiation to duplicate its genome when its endogenous origins are deleted. Similar non-canonical initiation events through break-induced...
cancer Cosmid Defective interfering particle Endogenousviralelement Fosmid Integrative and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid...
cancer Cosmid Defective interfering particle Endogenousviralelement Fosmid Integrative and conjugative element Jeewanu "Nanobacterium" Phagemid Plasmid...
Global Information