dosage compensation by inactivation of X chromosome
protein biosynthesis
regulation of translational initiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
10209
20918
Ensembl
ENSG00000173812
ENSMUSG00000035530
UniProt
P41567
P48024
RefSeq (mRNA)
NM_005801
NM_011508
RefSeq (protein)
NP_005792
NP_035638
Location (UCSC)
Chr 17: 41.69 – 41.69 Mb
Chr 11: 100.21 – 100.21 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Eukaryotic translation initiation factor 1 (eIF1) is a protein that in humans is encoded by the EIF1 gene. It is related to yeast SUI1.[5][6][7]
eIF1 interacts with the eukaryotic small (40S) ribosomal subunit and eIF3, and is a component of the 43S preinitiation complex (PIC).[8] eIF1 and eIF1A bind cooperatively to the 40S to stabilize an "open" conformation of the preinitiation complex (PIC) during eukaryotic translation initiation.[8] eIF1 binds to a region near the ribosomal P-site in the 40S subunit and functions in a manner similar to the structurally related bacterial counterpart IF3.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000173812 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000035530 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Fields C, Adams MD (January 1994). "Expressed sequence tags identify a human isolog of the suil translation initiation factor". Biochemical and Biophysical Research Communications. 198 (1): 288–91. doi:10.1006/bbrc.1994.1040. PMID 7904817.
^Sheikh MS, Fernandez-Salas E, Yu M, Hussain A, Dinman JD, Peltz SW, Huang Y, Fornace AJ (June 1999). "Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1))". The Journal of Biological Chemistry. 274 (23): 16487–93. doi:10.1074/jbc.274.23.16487. PMID 10347211.
translation initiation factor 1 (eIF1) is a protein that in humans is encoded by the EIF1 gene. It is related to yeast SUI1. eIF1 interacts with the eukaryotic...
Recognition of the start codon by the Met-tRNAiMet promotes gated phosphate and eIF1 release to form the 48S preinitiation complex (48S PIC), followed by large...
(i.e.., IF1, IF2, & IF3) and in eukaryotes they are known as eIFs (i.e.., eIF1, eIF2, eIF3). Translation initiation is sometimes described as three step...
contains the small ribosomal subunit (40S) bound by the initiation factors eIF1, eIF1A, eIF3, and the eIF2-Met-tRNAiMet-GTP ternary complex (eIF2-TC). The...
and described, as well as much about the 40S subunit's interaction with eIF1 during translation initiation. The eukaryotic 60S subunit structure was also...
the 40S subunit, as well as much about the 40S subunit's interaction with eIF1 during translation initiation. Similarly, the eukaryotic 60S subunit structure...
archaea. It is otherwise known as Eukaryotic translation initiation factor 1 (eIF1) in eukaryotes or YciH in bacteria. SUI1 is a translation initiation factor...
factors (eIFs) eIF2, eIF3, eIF5, and eIF5B, but do not require the factors eIF1, eIF1A, and the eIF4F complex. In contrast, picornavirus IRESs do not bind...
to form the 43S ribosome. Assisted by several other initiation factors (eIF1 and eIF1A, eIF5, eIF3, polyA binding protein) it is recruited to the 5′ end...
P-site, thus no ribosomal scanning is required. Consequently scanning factors eIF1 and eIF1A are dispensable for the HCV translation, as are components of the...
43S PIC assembly is believed to be stimulated by the initiation factors eIF1, eIF1A, and the eIF3 complex according to in vitro experiments. The 43S PIC...
Crystal structure of 40S ribosome in complex with its initiation factor eIF1 First demonstration that two of the "universal" stop codons, UAA and UAG...
but it does not seem to participate in translation initiation. aIF1: SUI1 (eIF1) homolog. aIF1A: IF1/eIF1A homolog. Plays a role in occupying the ribosomal...
JR, Ramakrishnan V (2007). "The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome". Molecular Cell...
this connection. However, both mammalian and yeast eIF3 independently bind eIF1, eIF4B, and eIF5. Several subunits of eIF3 contain RNA recognition motifs...