Hepatitis C virus internal ribosome entry site information
Hepatitis C virus internal ribosome entry site
Predicted secondary structure and sequence conservation of IRES_HCV
Identifiers
Symbol
IRES_HCV
Alt. Symbols
HCV_IRES
Rfam
RF00061
Other data
RNA type
Cis-reg; IRES
Domain(s)
Viruses
GO
GO:0043022
SO
SO:0000243
PDB structures
PDBe
The Hepatitis C virus internal ribosome entry site, or HCV IRES, is an RNA structure within the 5'UTR of the HCV genome that mediates cap-independent translation initiation.
Protein translation of most eukaryotic mRNAs occurs by a cap-dependent mechanism and requires association of Met-tRNAiMet, several eukaryotic initiation factors, and GTP with the 40S ribosomal subunit, recruitment to the 5' cap, and scanning along the 5' UTR to reach to start codon. In contrast, translation of hepatitis C virus (HCV) mRNA is initiated by a different mechanism from the usual 5' cap-binding model.[1] This alternate mechanism relies on the direct binding of the 40S ribosomal subunit by the internal ribosome entry site (IRES) in the 5' UTR of HCV RNA. The HCV IRES adopts a complex structure, and may differ significantly from IRES elements identified in picornaviruses. A small number of eukaryotic mRNAs has been shown to be translated by internal ribosome entry.[2][3]
^Lytle JR, Wu L, Robertson HD (August 2002). "Domains on the hepatitis C virus internal ribosome entry site for 40s subunit binding". RNA. 8 (8): 1045–1055. doi:10.1017/S1355838202029965. PMC 1370315. PMID 12212848.
^Beales LP, Rowlands DJ, Holzenburg A (May 2001). "The internal ribosome entry site (IRES) of hepatitis C virus visualized by electron microscopy". RNA. 7 (5): 661–670. doi:10.1017/S1355838201001406. PMC 1370118. PMID 11350030.
^Gallego J, Varani G (April 2002). "The hepatitis C virus internal ribosome-entry site: a new target for antiviral research". Biochemical Society Transactions. 30 (2): 140–145. doi:10.1042/BST0300140. PMID 12023841.
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an internalribosomeentrysite. On average, dsRNA viruses show a lower sequence redundancy relative to ssRNA viruses. Contrarily, dsDNA viruses contain...
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