Multiprotein complex that functions during the initiation phase of eukaryotic translation
Structure of rabbit eIF3 in the context of the 43S PIC, showing subunits a, c, e, f, h, k, l, and m.[1]
Eukaryotic initiation factor 3 (eIF3) is a multiprotein complex that functions during the initiation phase of eukaryotic translation.[2] It is essential for most forms of cap-dependent and cap-independent translation initiation. In humans, eIF3 consists of 13 nonidentical subunits (eIF3a-m) with a combined molecular weight of ~800 kDa, making it the largest translation initiation factor.[3] The eIF3 complex is broadly conserved across eukaryotes, but the conservation of individual subunits varies across organisms. For instance, while most mammalian eIF3 complexes are composed of 13 subunits, budding yeast's eIF3 has only six subunits (eIF3a, b, c, g, i, j).[4]
^des Georges, Amedee; Dhote, Vidya; Kuhn, Lauriane; Hellen, Christopher U.T.; Pestova, Tatyana V.; Frank, Joachim; Hashem, Yaser (2015). "Structure of mammalian eIF3 in the context of the 43S preinitiation complex". Nature. 525 (1770): 491–5. Bibcode:2015Natur.525..491D. doi:10.1038/nature14891. ISSN 0028-0836. PMC 4719162. PMID 26344199.
^Aitken, Colin E.; Lorsch, Jon R. (2012). "A mechanistic overview of translation initiation in eukaryotes". Nat. Struct. Mol. Biol. 19 (6): 568–576. doi:10.1038/nsmb.2303. PMID 22664984. S2CID 9201095.
^Hershey, John W.B. (2015). "The role of eIF3 and its individual subunits in cancer". Biochim. Biophys. Acta. 1849 (7): 792–800. doi:10.1016/j.bbagrm.2014.10.005. ISSN 1874-9399. PMID 25450521.
^Hinnebusch, Alan G. (2006). "eIF3: a versatile scaffold for translation initiation complexes". Trends Biochem. Sci. 31 (10): 553–562. doi:10.1016/j.tibs.2006.08.005. ISSN 0968-0004. PMID 16920360.
and 29 Related for: Eukaryotic initiation factor 3 information
Eukaryoticinitiationfactor3 (eIF3) is a multiprotein complex that functions during the initiation phase of eukaryotic translation. It is essential for...
Eukaryoticinitiationfactors (eIFs) are proteins or protein complexes involved in the initiation phase of eukaryotic translation. These proteins help...
factors): Many structural domains have been conserved through evolution, as prokaryotic initiationfactors share similar structures with eukaryotic factors...
Eukaryotic translation initiationfactor3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene. It is one of the subunits of Eukaryotic...
Eukaryotic translation initiationfactor3 subunit J (eIF3j) is a protein that in humans is encoded by the EIF3J gene. eIF3j has been shown to interact...
ribosomal subunit by eukaryoticinitiationfactor 2 (eIF2). It hydrolyzes GTP, and signals for the dissociation of several factors from the small ribosomal...
Eukaryotic translation initiationfactor3 subunit H (eIF3h) is a protein that in humans is encoded by the EIF3H gene. eIF3h has been shown to interact...
Eukaryotic translation initiationfactor3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene. Eukaryotic translation initiation...
Eukaryotic translation initiationfactor3 subunit F (eIF3f) is a protein that in humans is encoded by the EIF3F gene. EIF3F has been shown to interact...
EukaryoticInitiationFactor 2 (eIF2) is an eukaryoticinitiationfactor. It is required for most forms of eukaryotic translation initiation. eIF2 mediates...
Eukaryotic translation initiationfactor3 subunit G (eIF3g) is a protein that in humans is encoded by the EIF3G gene. EIF3G has been shown to interact...
Eukaryotic translation initiationfactor3 subunit C (eIF3c) is a protein that in humans is encoded by the EIF3C gene. EIF3C has been shown to interact...
the incorporation of free nucleotides into double-stranded DNA. Initiation of eukaryotic DNA replication is the first stage of DNA synthesis where the DNA...
Eukaryotic translation initiationfactor3 subunit K (eIF3k) is a protein that in humans is encoded by the EIF3K gene. The ~800 kDa eukaryotic initiation...
Eukaryotic translation initiationfactor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene. The protein encoded by this gene is a component...
Eukaryotic translation initiationfactor3 subunit E (eIF3e) is a protein that in humans is encoded by the EIF3E gene. EIF3S6 has been shown to interact...
Eukaryotic translation initiationfactor 4E, also known as eIF4E, is a protein that in humans is encoded by the EIF4E gene. Most eukaryotic cellular mRNAs...
Eukaryotic translation initiationfactor3 subunit B (eIF3b) is a protein that in humans is encoded by the EIF3B gene. EIF3B has been shown to interact...
Eukaryotic transcription is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of transportable complementary...
Eukaryotic translation initiationfactor3 subunit C like is a protein that in humans is encoded by the EIF3CL gene. The protein encoded by this gene is...
Eukaryotic translation initiationfactor3 subunit I (eIF3i) is a protein that in humans is encoded by the EIF3I gene. eIF3i has been shown to interact...
N (Feb 2011). "Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiationfactor 1". Science. 331 (6018): 730–736. Bibcode:2011Sci...
factor (σ factor or specificity factor) is a protein needed for initiation of transcription in bacteria. It is a bacterial transcription initiation factor...
to viral nucleic acids and the other, by directly binding to eukaryoticinitiationfactor3 (eIF3) and preventing eIF3 from initiating the translational...
The eukaryoticinitiationfactor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the...
Eukaryotic translation initiationfactor3, subunit M (eIF3m) also known as PCI domain containing 1 (herpesvirus entry mediator) (PCID1), is a protein...
Eukaryotic translation initiationfactor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene. The protein encoded by this gene...
Eukaryotic translation initiationfactor 5 is a protein that in humans is encoded by the EIF5 gene. EIF5 is a GTPase-activating protein. GRCh38: Ensembl...
transcription factors are necessary for transcription to occur. In bacteria, transcription initiation requires an RNA polymerase and a single GTF: sigma factor. In...
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