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Drug accumulation ratio information


In pharmacokinetics, the drug accumulation ratio (Rac) is the ratio of accumulation of a drug under steady state conditions (i.e., after repeated administration) as compared to a single dose. The higher the value, the more the drug accumulates in the body. An Rac of 1 means no accumulation.

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Drug accumulation ratio

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In pharmacokinetics, the drug accumulation ratio (Rac) is the ratio of accumulation of a drug under steady state conditions (i.e., after repeated administration)...

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Bioaccumulation

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(magnification of toxins with increasing trophic level) Chelation therapy Drug accumulation ratio Environmental impact of pesticides International POPs Elimination...

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Nanoparticle drug delivery

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can be beneficial for drug delivery systems. Some important advantages of nanoparticles are their high surface-area-to-volume ratio, chemical and geometric...

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Partition coefficient

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Rate constants and equilibrium ratios for accumulation of organic substances related to octanol-water partition ratio and species weight". Environmental...

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Orphan drug

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a rare hereditary disease that can lead to a fatal accumulation of copper in the body. This drug was later found to be effective in treating arthritis...

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Hepatotoxicity

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inhibition: Some drugs may share the same P-450 specificity and thus competitively block their biotransformation. This may lead to accumulation of drugs metabolized...

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Drug rash with eosinophilia and systemic symptoms

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Drug rash with eosinophilia and systemic symptoms or drug reaction with eosinophilia and systemic symptoms (DRESS), also termed drug-induced hypersensitivity...

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Liver function tests

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Alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD), fat accumulation in liver during childhood obesity, steatohepatitis (inflammation of fatty...

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Amphetamine

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short-lived Fos family proteins after acute drug exposure to the predominant accumulation of ΔFosB after chronic drug exposure Kanehisa Laboratories (10 October...

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Cyclodextrin

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from starch by enzymatic conversion. They are used in food, pharmaceutical, drug delivery, and chemical industries, as well as agriculture and environmental...

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Nanocarrier

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nanocarriers become trapped, the drug accumulates at the tumor site. This accumulation causes large doses of the drug to be delivered directly to the tumor...

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Addiction

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short-lived Fos family proteins after acute drug exposure to the predominant accumulation of ΔFosB after chronic drug exposure Hyman SE, Malenka RC, Nestler...

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Adderall

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short-lived Fos family proteins after acute drug exposure to the predominant accumulation of ΔFosB after chronic drug exposure Kanehisa Laboratories (10 October...

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Elagolix

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with peak concentrations occurring after 0.5 to 1.5 hours. The drug accumulation ratio of elagolix at 150 mg once per day is 0.98 and at 200 mg twice...

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Investment

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debt-to-equity ratio with those of other companies in the same industry, and examine trends in debt-to-equity ratios and free cashflow. Capital accumulation Capital...

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Amiodarone

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amiodarone and DEA in the placenta as well as a presence in breast milk. Accumulation of amiodarone and DEA occurs in adipose tissue and highly perfused organs...

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Diclofenac

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the brand name Voltaren, among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. It is...

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Temazepam

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of the accumulation of temazepam over seven days in elderly inpatients, and found little tolerance developed during the accumulation of the drug. Other...

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Remifentanil

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the brand name Ultiva is a potent, short-acting synthetic opioid analgesic drug. It is given to patients during surgery to relieve pain and as an adjunct...

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Equianalgesic

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chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of...

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Carbamazepine

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Field and laboratory studies have been conducted to understand the accumulation of carbamazepine in food plants grown in soil treated with sludge, which...

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Lactic acidosis

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composition and shell allow it to tolerate high levels of lactic acid accumulation. In the anoxic conditions where fermentation is dominant, calcium levels...

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PEGylation

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called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated. PEGylation...

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Oxazepam

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a low chance of accumulation and a relatively slow absorption speed. Oxazepam has the potential for misuse, defined as taking the drug to achieve a high...

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