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Remifentanil information


Remifentanil
Clinical data
Trade namesUltiva
Other namesmethyl 1-(2-methoxycarbonylethyl)-4-(phenyl-propanoyl-amino)-piperidine-4-carboxylate
AHFS/Drugs.comMonograph
Pregnancy
category
  • AU: C
Routes of
administration
Intravenous
ATC code
  • N01AH06 (WHO)
Legal status
Legal status
  • AU: S8 (Controlled drug)
  • BR: Class A1 (Narcotic drugs)[1]
  • CA: Schedule I
  • DE: Anlage III (Special prescription form required)
  • UK: Class A
  • US: Schedule II
Pharmacokinetic data
Bioavailability0
Protein binding70% (bound to plasma proteins)
Metabolismcleaved by non-specific plasma and tissue esterases
Elimination half-life1-20 minutes
Identifiers
IUPAC name
  • methyl 1-(3-methoxy-3-oxopropyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate
CAS Number
  • 132875-61-7 checkY
PubChem CID
  • 60815
IUPHAR/BPS
  • 7292
DrugBank
  • DB00899 checkY
ChemSpider
  • 54803 checkY
UNII
  • P10582JYYK
KEGG
  • D08473 checkY
  • as HCl: D01177 checkY
ChEBI
  • CHEBI:8802 checkY
ChEMBL
  • ChEMBL1005 checkY
CompTox Dashboard (EPA)
  • DTXSID00157826 Edit this at Wikidata
ECHA InfoCard100.211.201 Edit this at Wikidata
Chemical and physical data
FormulaC20H28N2O5
Molar mass376.453 g·mol−1
3D model (JSmol)
  • Interactive image
Melting point5 °C (41 °F)
SMILES
  • O=C(OC)C2(N(c1ccccc1)C(=O)CC)CCN(CCC(=O)OC)CC2
InChI
  • InChI=1S/C20H28N2O5/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2/h5-9H,4,10-15H2,1-3H3 checkY
  • Key:ZTVQQQVZCWLTDF-UHFFFAOYSA-N checkY
  (verify)

Remifentanil, marketed under the brand name Ultiva is a potent, short-acting synthetic opioid analgesic drug. It is given to patients during surgery to relieve pain and as an adjunct to an anaesthetic. Remifentanil is used for sedation as well as combined with other medications for use in general anesthesia. The use of remifentanil has made possible the use of high-dose opioid and low-dose hypnotic anesthesia, due to synergism between remifentanil and various hypnotic drugs and volatile anesthetics.

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

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