Ropinirole information

Ropinirole
Clinical data
Trade names	Requip, Repreve, Ronirol, others
AHFS/Drugs.com	Monograph
MedlinePlus	a698013
License data	US DailyMed: Ropinirole;
Routes of; administration	By mouth
ATC code	N04BC04 (WHO) ; QV03AB96 (WHO);
Legal status
Legal status	BR: Class C1 (Other controlled substances); US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	50%
Metabolism	Liver (CYP1A2)
Elimination half-life	5-6 hours
Identifiers
	IUPAC name 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one;
CAS Number	91374-21-9 ;
PubChem CID	5095;
IUPHAR/BPS	7295;
DrugBank	DB00268 ;
ChemSpider	4916 ;
UNII	030PYR8953;
KEGG	D08489 ;
ChEBI	CHEBI:8888 ;
ChEMBL	ChEMBL589 ;
CompTox Dashboard (EPA)	DTXSID8045195 ;
ECHA InfoCard	100.110.353
Chemical and physical data
Formula	C16H24N2O
Molar mass	260.381 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2Nc1cccc(c1C2)CCN(CCC)CCC;
	InChI InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19) ; Key:UHSKFQJFRQCDBE-UHFFFAOYSA-N ;
	(verify)

Ropinirole, sold under the brand name Requip among others, is a medication used to treat Parkinson's disease (PD) and restless legs syndrome (RLS).^[3] It is taken by mouth.^[4]

Common side effects include sleepiness, vomiting, and dizziness.^[4] Serious side effects may include pathological gambling, low blood pressure with standing and hallucinations.^[3]^[4] Use in pregnancy and breastfeeding is of unclear safety.^[5] It is a dopamine agonist and works by triggering dopamine D₂ receptors.^[4]

It was approved for medical use in the United States in 1997.^[4] It is available as a generic medication.^[3] In 2021, it was the 142nd most commonly prescribed medication in the United States, with more than 4 million prescriptions.^[6]^[7]

^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^ ^a ^b ^c Tompson DJ, Vearer D (December 2007). "Steady-state pharmacokinetic properties of a 24-hour prolonged-release formulation of ropinirole: results of two randomized studies in patients with Parkinson's disease". Clinical Therapeutics. 29 (12): 2654–2666. doi:10.1016/j.clinthera.2007.12.010. PMID 18201581.
^ ^a ^b ^c British National Formulary (76th ed.). Pharmaceutical Press. 2018. pp. 419–420. ISBN 978-0-85711-338-2.
^ ^a ^b ^c ^d ^e "Ropinirole Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
^ "Ropinirole Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^ "Ropinirole - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

[1] Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.

[TompsonD-2] Tompson DJ, Vearer D (December 2007). "Steady-state pharmacokinetic properties of a 24-hour prolonged-release formulation of ropinirole: results of two randomized studies in patients with Parkinson's disease". Clinical Therapeutics. 29 (12): 2654–2666. doi:10.1016/j.clinthera.2007.12.010. PMID 18201581.

[BNF76-3] British National Formulary (76th ed.). Pharmaceutical Press. 2018. pp. 419–420. ISBN 978-0-85711-338-2.

[AHFS2019-4] "Ropinirole Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[Preg2019-5] "Ropinirole Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.

[6] "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.

[7] "Ropinirole - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

Ropinirole information

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