Dimdazenil information

Dimdazenil
Clinical data
Trade names	Junoenil
Other names	EVT-201
Legal status
Legal status	Rx in China;
Identifiers
	IUPAC name 7-Chloro-3-[5-[(dimethylamino)methyl]-1,2,4-oxadiazol-3-yl]-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one;
CAS Number	308239-86-3;
PubChem CID	9885841;
DrugBank	DB05721;
ChemSpider	8061514;
UNII	6J8AF7CLE4;
ChEMBL	ChEMBL5095096;
CompTox Dashboard (EPA)	DTXSID301032055 ;
Chemical and physical data
Formula	C17H17ClN6O2
Molar mass	372.81 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc4cccc3n2cnc(c1nc(on1)CN(C)C)c2CN(C(=O)c34)C;
	InChI InChI=1S/C17H17ClN6O2/c1-22(2)8-13-20-16(21-26-13)15-12-7-23(3)17(25)14-10(18)5-4-6-11(14)24(12)9-19-15/h4-6,9H,7-8H2,1-3H3; Key:JCYLWUVDHLVGER-UHFFFAOYSA-N;

Dimdazenil (trade name Junoenil) is a pharmaceutical drug for insomnia.^[1] It is a benzodiazepine derivative and a partial positive allosteric modulator of the GABA_A receptor^[2] with two- to four-fold higher functional affinity for the α₁ subunit relative to the α₂, α₃, and α₅ subunits.

^ Huang Z, Zhan S, Chen C, Zhang R, Zhou Y, He J, et al. (February 2024). "Efficacy and safety of Dimdazenil in adults with insomnia disorder: results from a multicenter, randomized, double-blind, placebo-controlled phase III trials". Sleep. 47 (2). doi:10.1093/sleep/zsad272. PMC 10851846. PMID 37875349.
^ Guilleminault C (2010). Sleep Medicine. Elsevier Health Sciences. pp. 574–. ISBN 978-1-4377-1836-2.

[1] Huang Z, Zhan S, Chen C, Zhang R, Zhou Y, He J, et al. (February 2024). "Efficacy and safety of Dimdazenil in adults with insomnia disorder: results from a multicenter, randomized, double-blind, placebo-controlled phase III trials". Sleep. 47 (2). doi:10.1093/sleep/zsad272. PMC 10851846. PMID 37875349.

[Guilleminault2010-2] Guilleminault C (2010). Sleep Medicine. Elsevier Health Sciences. pp. 574–. ISBN 978-1-4377-1836-2.

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