This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages)
This article relies excessively on references to primary sources. Please improve this article by adding secondary or tertiary sources. Find sources: "Dichloropane" – news · newspapers · books · scholar · JSTOR(February 2016) (Learn how and when to remove this message)
This article may be too technical for most readers to understand. Please help improve it to make it understandable to non-experts, without removing the technical details.(February 2016) (Learn how and when to remove this message)
Dichloropane ((−)-2β-Carbomethoxy-3β-(3,4-dichlorophenyl)tropane, RTI-111, O-401) is a stimulant of the phenyltropane class that acts as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with IC50 values of 3.13, 18, and 0.79 nM, respectively.[1] In animal studies, dichloropane had a slower onset and longer duration of action compared to cocaine.[2][3]
Methylecgonidine is the direct precursor to this compound.[4]
^Carroll FI, Blough BE, Nie Z, Kuhar MJ, Howell LL, Navarro HA (April 2005). "Synthesis and monoamine transporter binding properties of 3beta-(3',4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters". Journal of Medicinal Chemistry. 48 (8): 2767–71. doi:10.1021/jm040185a. PMID 15828814.
^Ranaldi R, Anderson KG, Carroll FI, Woolverton WL (December 2000). "Reinforcing and discriminative stimulus effects of RTI 111, a 3-phenyltropane analog, in rhesus monkeys: interaction with methamphetamine". Psychopharmacology. 153 (1): 103–10. doi:10.1007/s002130000602. PMID 11255920. S2CID 29716872.
^Cook CD, Carroll IF, Beardsley PM (December 2001). "Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat". Psychopharmacology. 159 (1): 58–63. doi:10.1007/s002130100891. PMID 11797070. S2CID 25696981.
^Carroll FI, Mascarella SW, Kuzemko MA, Gao Y, Abraham P, Lewin AH, et al. (September 1994). "Synthesis, ligand binding, and QSAR (CoMFA and classical) study of 3 beta-(3'-substituted phenyl)-, 3 beta-(4'-substituted phenyl)-, and 3 beta-(3',4'-disubstituted phenyl)tropane-2 beta-carboxylic acid methyl esters". Journal of Medicinal Chemistry. 37 (18): 2865–73. doi:10.1021/jm00044a007. PMID 8071935.
research for the manufacture of phenyltropane analogues such as troparil, dichloropane, iometopane, and CFT. Methylecgonidine could also theoretically be used...
C15H17Cl2NO2 (molar mass: 314.207 g/mol) may refer to: Bemesetron (MDL-72222) Dichloropane This set index page lists chemical structure articles associated with...