Enzyme that breaks down diacylglycerol in many organisms.
diacylglycerol lipase α
DAGLα structure, folded with AlphaFold.[1][2][3]
Transmembrane domain in marine blue. Catalytic domain in yellow. C-terminal tail in gray. See Structure for details. Click image for higher resolution.
Identifiers
Symbol
DAGLA
Alt. symbols
C11orf11
NCBI gene
747
HGNC
1165
RefSeq
NM_006133
UniProt
Q9Y4D2
Other data
EC number
3.1.1.116
Locus
Chr. 11 q12.3
Search for
Structures
Swiss-model
Domains
InterPro
diacylglycerol lipase β
DAGLβ structure, folded with AlphaFold.[1][2][3] Transmembrane domain in marine blue. Catalytic domain in yellow. Note missing C-terminal tail. See Structure for details. Click image for higher resolution.
Identifiers
Symbol
DAGLB
NCBI gene
221955
HGNC
28923
RefSeq
NM_139179
UniProt
Q8NCG7
Other data
EC number
3.1.1.116
Locus
Chr. 7 p22.1
Search for
Structures
Swiss-model
Domains
InterPro
Diacylglycerol lipase, also known as DAG lipase, DAGL, or DGL, is an enzyme that catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol:[1]
DAGL has been studied in multiple domains of life, including bacteria, fungi, plants, insects, and mammals.[4] By searching with BLAST for the previously sequenced microorganism DAGL,[5] Bisogno et al discovered two distinct mammalian isoforms, designated DAGLα (DAGLA) and DAGLβ (DAGLB).[1] Most animal DAGL enzymes cluster into the DAGLα and DAGLβ isoforms.[4]
Mammalian DAGL is a crucial enzyme in the biosynthesis of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid in tissues.[1] The endocannabinoid system has been identified to have considerable involvement in the regulation of homeostasis and disease.[6] As a result, much effort has been made toward investigating the mechanisms of action and the therapeutic potential of the system's receptors, endogenous ligands, and enzymes like DAGLα and DAGLβ.[6]
^ abcdeBisogno T, Howell F, Williams G, et al. (November 2003). "Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain". J. Cell Biol. 163 (3): 463–8. doi:10.1083/jcb.200305129. PMC 2173631. PMID 14610053.
^ abJumper, John; Evans, Richard; Pritzel, Alexander; Green, Tim; Figurnov, Michael; Ronneberger, Olaf; Tunyasuvunakool, Kathryn; Bates, Russ; Žídek, Augustin; Potapenko, Anna; Bridgland, Alex; Meyer, Clemens; Kohl, Simon A. A.; Ballard, Andrew J.; Cowie, Andrew (2021-07-15). "Highly accurate protein structure prediction with AlphaFold". Nature. 596 (7873): 583–589. Bibcode:2021Natur.596..583J. doi:10.1038/s41586-021-03819-2. ISSN 1476-4687. PMC 8371605. PMID 34265844.
^ abMirdita, Milot; Schütze, Konstantin; Moriwaki, Yoshitaka; Heo, Lim; Ovchinnikov, Sergey; Steinegger, Martin (2022-05-30). "ColabFold: making protein folding accessible to all". Nature Methods. 19 (6): 679–682. doi:10.1038/s41592-022-01488-1. ISSN 1548-7105. PMC 9184281. PMID 35637307.
^ abYuan, Dongjuan; Wu, Zhongdao; Wang, Yonghua (2016-08-26). "Evolution of the diacylglycerol lipases". Progress in Lipid Research. 64: 85–97. doi:10.1016/j.plipres.2016.08.004. ISSN 1873-2194. PMID 27568643.
^Yamaguchi, Shotaro; Tamio, Mase; Kazuyuki, Takeuchi (1991-07-15). "Cloning and structure of the mono- and diacylglycerol lipase-encoding gene from Penicillium camembertii U-150". Gene. 103 (1): 61–67. doi:10.1016/0378-1119(91)90391-N. ISSN 0378-1119. PMID 1879699.
Diacylglycerollipase, also known as DAG lipase, DAGL, or DGL, is an enzyme that catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid...
organisms. Classically, lipases catalyse the hydrolysis of triglycerides: triglyceride + H 2 O ⟶ fatty acid + diacylglyceroldiacylglycerol + H 2 O ⟶ fatty acid...
Lingual lipase is a member of a family of digestive enzymes called triacylglycerol lipases, EC 3.1.1.3, that use the catalytic triad of aspartate, histidine...
Lipoprotein lipase (LPL) (EC 3.1.1.34, systematic name triacylglycerol acylhydrolase (lipoprotein-dependent)) is a member of the lipase gene family, which...
diacylglycerol + a carboxylate These lipases are widely distributed in animals, plants and prokaryotes. This family was also called class 3 lipases as...
lipases, including hormone sensitive lipase, monoacylglycerol lipase, adipose triglyceride lipase, and diacylglycerollipase Cholinesterases, including acetylcholinesterase...
Fatty acids and diacylglycerols are produced from this reaction. The long chain free fatty acids have the ability to prevent gastric lipase from hydrolyzing...
Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that in humans is encoded by the...
hydrolysis of triglycerides by lipoprotein lipase and the enzymatic hydrolysis of diglycerides by diacylglycerollipase; or as an intermediate in the alkanoylation...
lysophospholipase. Phospholipase C – cleaves before the phosphate, releasing diacylglycerol and a phosphate-containing head group. PLCs play a central role in signal...
triglyceride lipase (ATGL). This enzyme catalyzes the hydrolysis of triacylglycerol to diacylglycerol. Subsequently, hormone-sensitive lipase (HSL) catalyzes...
Hepatic lipase (HL), also called hepatic triglyceride lipase (HTGL) or LIPC (for "lipase, hepatic"), is a form of lipase, catalyzing the hydrolysis of...
breakdown of a lipid product of PLC cascade, diacylglycerol (DAG), by the enzyme diacylglycerollipase, generates PUFAs that can activate TRP channels...
could refer to: Deglycyrrhizinated licorice, a herbal supplement Diacylglycerollipase, an enzyme Dingle Road railway station, Wales (by code) Douglas...
produced when phospholipase C releases diacylglycerol which is then converted to 2-AG by diacylglycerollipase. 2-AG can also activate both cannabinoid...
Monoacylglycerol lipase (EC 3.1.1.23; systematic name glycerol-ester acylhydrolase, also known as MAG lipase, acylglycerol lipase, MAGL, MGL or MGLL) is...
Lipase inhibitors belong to a drug class that is used as an antiobesity agent. Their mode of action is to inhibit gastric and pancreatic lipases, enzymes...
their storage form as triglycerides (or fats), is carried out by lipases. These lipases are activated by high epinephrine and glucagon levels in the blood...
extremely low levels. In general, various phospholipase A2s and diacylglycerollipases are activated during cell stimulation, proceed to release these...
is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction...
levels confounded these findings. Instead, IMTG metabolites, such as diacylglycerol and ceramide are responsible for the insulin resistance. Studies demonstrating...
the inositol trisphosphate group, yielding diacylglycerol (DAG), which subsequently is cleaved by DAG lipase to yield arachidonic acid. Receptors that...
by the enzyme phospholipase C into inositol triphosphate (IP3) and diacylglycerol (DAG), which both carry out the functions of the Gq type of G protein...
proteins, and cofactors for enzymes (e.g. apolipoprotein C-II for lipoprotein lipase and apolipoprotein A-I (apoA1) for lecithin-cholesterol acyltransferase)...
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