Lingual Lipase with catalytic triad highlighted in center
Identifiers
Symbol
LIPF
Alt. names
Triacylglycerol,
Other data
EC number
3.1.1.3
Lingual lipase is a member of a family of digestive enzymes called triacylglycerol lipases, EC 3.1.1.3, that use the catalytic triad of aspartate, histidine, and serine to hydrolyze medium and long-chain triglycerides into partial glycerides and free fatty acids. The enzyme, released into the mouth along with the saliva, catalyzes the first reaction in the digestion of dietary lipid, with diglycerides being the primary reaction product.[1] However, due to the unique characteristics of lingual lipase, including a pH optimum 4.5–5.4 and its ability to catalyze reactions without bile salts, the lipolytic activity continues through to the stomach.[2] Enzyme release is signaled by autonomic nervous system after ingestion, at which time the serous glands under the circumvallate and foliate lingual papillae on the surface of the tongue[3] secrete lingual lipase to the grooves of the circumvallate and foliate papillae, co-localized with fat taste receptors. The hydrolysis of the dietary fats is essential for fat absorption by the small intestine, as long chain triacylglycerides cannot be absorbed, and as much as 30% of fat is hydrolyzed within 1 to 20 minutes of ingestion by lingual lipase alone.[2]
Lingual lipase, together with gastric lipase, comprise the two acidic lipases.
^Hamosh M, Scow RO (January 1973). "Lingual lipase and its role in the digestion of dietary lipid". The Journal of Clinical Investigation. 52 (1): 88–95. doi:10.1172/JCI107177. PMC 302230. PMID 4682389.
^ abCleghorn GJ, Shepherd RW (1989). Cystic fibrosis: nutritional and intestinal disorders. Boca Raton: CRC Press. ISBN 978-0-8493-6954-4.
^Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (November 2006). "The receptors and cells for mammalian taste". Nature. 444 (7117): 288–94. doi:10.1038/nature05401. PMID 17108952.
Linguallipase is a member of a family of digestive enzymes called triacylglycerol lipases, EC 3.1.1.3, that use the catalytic triad of aspartate, histidine...
biochemistry, lipase (/ˈlaɪpeɪs, ˈlaɪpeɪz/ LY-payss, LY-payz) refers to a class of enzymes that catalyzes the hydrolysis of fats. Some lipases display broad...
Gastric lipase, together with linguallipase, comprise the two acidic lipases. These lipases, unlike alkaline lipases (such as pancreatic lipase), do not...
place in the mouth. Saliva contains the digestive enzymes amylase, and linguallipase, secreted by the salivary and serous glands on the tongue. Chewing,...
Pancreatic lipase Gastric lipaseLinguallipase Chapus C, Rovery M, Sarda L, Verger R (1988). "Minireview on pancreatic lipase and colipase". Biochimie...
Gastric lipase, together with linguallipase, comprise the two acidic lipases. These lipases, unlike alkaline lipases (such as pancreatic lipase), do not...
monoglyceride units with the help of lipase enzymes. Digestion of fats begin in the mouth through chemical digestion by linguallipase. Ingested cholesterol is not...
pancreatic, hepatic and gastric/lingual. These lipases are closely related to each other and to lipoprotein lipase (EC 3.1.1.34), which hydrolyses triglycerides...
starch before the food is even swallowed; it has a pH optimum of 7.4 Linguallipase, which is secreted by the acinar cells of the sublingual gland; has...
acidity of which inactivates salivary amylase and activates linguallipase. Linguallipase then begins breaking down triglycerides into free fatty acids...
S; Abumrad, N. A. (2012). "The fatty acid translocase gene CD36 and linguallipase influence oral sensitivity to fat in obese subjects". The Journal of...
circumvallate and foliate papillae, which are present in taste buds and where linguallipase is produced, and research has shown that the CD36 receptor binds long...
smaller polypeptides. Digestion of some fats can begin in the mouth where linguallipase breaks down some short chain lipids into diglycerides. However fats...
Abumrad NA (March 2012). "The fatty acid translocase gene CD36 and linguallipase influence oral sensitivity to fat in obese subjects". Journal of Lipid...
Christopher C. (2003). "Weight Gain in Gonadectomized Normal and Lipoprotein Lipase–Deficient Male Domestic Cats Results from Increased Food Intake and Not...
milk contains several anti-infective factors such as bile salt stimulated lipase (protecting against amoebic infections) and lactoferrin (which binds to...
for diagnosis. In cases of pancreatitis, there may be elevated levels of lipase or amylase, an enzyme found in saliva and the pancreas. Mumps orchitis is...
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