Hepatic lipase (HL), also called hepatic triglyceride lipase (HTGL) or LIPC (for "lipase, hepatic"), is a form of lipase, catalyzing the hydrolysis of triacylglyceride. Hepatic lipase is coded by chromosome 15 and its gene is also often referred to as HTGL or LIPC.[5] Hepatic lipase is expressed mainly in liver cells, known as hepatocytes, and endothelial cells of the liver. The hepatic lipase can either remain attached to the liver or can unbind from the liver endothelial cells and is free to enter the body's circulation system.[6] When bound on the endothelial cells of the liver, it is often found bound to heparan sulfate proteoglycans (HSPG), keeping HL inactive and unable to bind to HDL (high-density lipoprotein) or IDL (intermediate-density lipoprotein).[7] When it is free in the bloodstream, however, it is found associated with HDL to maintain it inactive. This is because the triacylglycerides in HDL serve as a substrate, but the lipoprotein contains proteins around the triacylglycerides that can prevent the triacylglycerides from being broken down by HL.[8]
One of the principal functions of hepatic lipase is to convert intermediate-density lipoprotein (IDL) to low-density lipoprotein (LDL). Hepatic lipase thus plays an important role in triglyceride level regulation in the blood by maintaining steady levels of IDL, HDL and LDL.[5]
Horse pancreatic lipase; believed to have a similar structure to Homo sapiens hepatic lipase as both show similar amino acid sequences.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000166035 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032207 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abFox SI (2015). Human physiology (Fourteenth ed.). New York, NY. ISBN 978-0-07-783637-5. OCLC 895500922.{{cite book}}: CS1 maint: location missing publisher (link)
^Cite error: The named reference pmid16397139 was invoked but never defined (see the help page).
^Cite error: The named reference Chatterjee_2011 was invoked but never defined (see the help page).
^Cite error: The named reference Cedó_2017 was invoked but never defined (see the help page).
^Bourne Y, Cambillau C (1994). "Horse Pancreatic Lipase. The Crystal Structure at 2.3 Angstroms Resolution". J. Mol. Biol. 238. doi:10.2210/pdb1hpl/pdb.
Hepaticlipase (HL), also called hepatic triglyceride lipase (HTGL) or LIPC (for "lipase, hepatic"), is a form of lipase, catalyzing the hydrolysis of...
biochemistry, lipase (/ˈlaɪpeɪs, ˈlaɪpeɪz/ LY-payss, LY-payz) refers to a class of enzymes that catalyzes the hydrolysis of fats. Some lipases display broad...
of the lipase gene family, which includes pancreatic lipase, hepaticlipase, and endothelial lipase. It is a water-soluble enzyme that hydrolyzes triglycerides...
Uptake of HDL2 is mediated by hepaticlipase, a special form of lipoprotein lipase found only in the liver. Hepaticlipase activity is increased by androgens...
vertebrates, pancreatic, hepatic and gastric/lingual. These lipases are closely related to each other and to lipoprotein lipase (EC 3.1.1.34), which hydrolyses...
cholesterol-lowering drug but was pulled due to cardiac side-effects. It increases hepaticlipase which in turn improves utilization of triglycerides and decreases levels...
absorbed by the liver, or they can be further hydrolyzed by hepaticlipase. Hydrolysis by hepaticlipase releases glycerol and fatty acids, leaving behind IDL...
cholesterol metabolising genes such as the hepaticlipase, cholesterol ester transferase, lipoprotein lipase and the ATP-binding cassette A1 correlate...
animal species. It receives bile, produced by the liver, via the common hepatic duct, and stores it. The bile is then released via the common bile duct...
to: Electrolaser (Laser-Induced Plasma Channel) LIPC gene encoding hepaticlipase The ICAO code for Cervia Air Force Base This disambiguation page lists...
Acid lipase disease or deficiency is a name used to describe two related disorders of fatty acid metabolism. Acid lipase disease occurs when the enzyme...
damage (loss of function of 80–90% of liver cells). The complications are hepatic encephalopathy and impaired protein synthesis (as measured by the levels...
phospholipase A1 and lysophospholipase but not triacyl glycerol lipase activities of rat liver hepaticlipase". FEBS Letters. 296 (3): 237–240. doi:10.1016/0014-5793(92)80294-Q...
monoglyceride units with the help of lipase enzymes. Digestion of fats begin in the mouth through chemical digestion by lingual lipase. Ingested cholesterol is not...
triglyceride lipase (ATGL). This enzyme catalyzes the hydrolysis of triacylglycerol to diacylglycerol. Subsequently, hormone-sensitive lipase (HSL) catalyzes...
CT scans, and through blood tests such as measurement of the amylase and lipase enzymes.: 888–894 Diseases of the hepatobiliary system affect the biliary...
state: "It is usually not necessary to measure both serum amylase and lipase. Serum lipase may be preferable because it remains normal in some nonpancreatic...
in the mouth. Saliva contains the digestive enzymes amylase, and lingual lipase, secreted by the salivary and serous glands on the tongue. Chewing, in which...
"Overexpression of hepaticlipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins Evidence that hepaticlipase acts as a...
unknown. Gemfibrozil increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. It does so...
contributions to disease. In 2010, Neale wrote about the function of the hepaticlipase gene, LIPC. The experiment found an association between advanced age-related...
hyperlipoproteinemia exists in several forms: Lipoprotein lipase deficiency (type Ia), due to a deficiency of lipoprotein lipase (LPL) or altered apolipoprotein C2, resulting...
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