Discovery and development of gastrointestinal lipase inhibitors information
Lipase inhibitor
Drug class
Chemical structure of the lipase inhibitor Orlistat[1]
Class identifiers
ATC code
A08AB
Mode of action
Inhibits gastric lipase and pancreatic lipase
Legal status
In Wikidata
Lipase inhibitors belong to a drug class that is used as an antiobesity agent. Their mode of action is to inhibit gastric and pancreatic lipases, enzymes that play an important role in the digestion of dietary fat.[2] Lipase inhibitors are classified in the ATC-classification system as A08AB (peripherally acting antiobesity products).[3]
Numerous compounds have been either isolated from nature, semi-synthesized, or fully synthesized and then screened for their lipase inhibitory activity[4] but the only lipase inhibitor on the market (October 2016) is orlistat (Xenical, Alli).[5]
Lipase inhibitors have also shown anticancer activity, by inhibiting fatty acid synthase.[6]
^Cite error: The named reference Schaefer_2015 was invoked but never defined (see the help page).
^Guerciolini R (June 1997). "Mode of action of orlistat". International Journal of Obesity and Related Metabolic Disorders. 21 (Suppl 3): S12–23. PMID 9225172.
^"All centralized human medicinal product by ATC code". Public Health. European Commission. Retrieved 1 October 2016.
^Cite error: The named reference Lunagariya_2014 was invoked but never defined (see the help page).
^Cite error: The named reference Bai_2014 was invoked but never defined (see the help page).
^Purohit VC, Richardson RD, Smith JW, Romo D (June 2006). "Practical, catalytic, asymmetric synthesis of beta-lactones via a sequential ketene dimerization/hydrogenation process: inhibitors of the thioesterase domain of fatty acid synthase". The Journal of Organic Chemistry. 71 (12): 4549–58. doi:10.1021/jo060392d. PMID 16749788.
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