Reaction catalyzed by MGLL, in which a free fatty acid (FFA) is released from a monoacylglycerol (MAG)
Identifiers
EC no.
3.1.1.23
CAS no.
9040-75-9
Databases
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
RCSB PDB PDBe PDBsum
Gene Ontology
AmiGO / QuickGO
Search
PMC
articles
PubMed
articles
NCBI
proteins
monoglyceride lipase
Identifiers
Symbol
MGLL
NCBI gene
11343
HGNC
17038
OMIM
609699
RefSeq
NM_007283
UniProt
Q99685
Other data
EC number
3.1.1.23
Locus
Chr. 3 p13-q13.33
Search for
Structures
Swiss-model
Domains
InterPro
Monoacylglycerol lipase (EC 3.1.1.23; systematic name glycerol-ester acylhydrolase, also known as MAG lipase, acylglycerol lipase, MAGL, MGL or MGLL) is an enzyme that, in humans, is encoded by the MGLL gene.[1][2][3] MAGL is a 33-kDa, membrane-associated member of the serine hydrolase superfamily and contains the classical GXSXG consensus sequence common to most serine hydrolases. The catalytic triad has been identified as Ser122, His269, and Asp239.[2][4]
Human monoacylglycerol lipase
^Wall EM, Cao J, Chen N, Buller RM, Upton C (December 1997). "A novel poxvirus gene and its human homolog are similar to an E. coli lysophospholipase". Virus Research. 52 (2): 157–67. doi:10.1016/S0168-1702(97)00122-6. PMID 9495531.
^ abKarlsson M, Contreras JA, Hellman U, Tornqvist H, Holm C (October 1997). "cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases". The Journal of Biological Chemistry. 272 (43): 27218–23. doi:10.1074/jbc.272.43.27218. PMID 9341166.
^"Entrez Gene: monoglyceride lipase".
^Tornqvist H, Belfrage P (February 1976). "Purification and some properties of a monoacylglycerol-hydrolyzing enzyme of rat adipose tissue". The Journal of Biological Chemistry. 251 (3): 813–9. doi:10.1016/S0021-9258(17)33857-7. PMID 1249056.
and 25 Related for: Monoacylglycerol lipase information
Monoacylglycerollipase (EC 3.1.1.23; systematic name glycerol-ester acylhydrolase, also known as MAG lipase, acylglycerol lipase, MAGL, MGL or MGLL)...
hydrolysis of diacylglycerol to monoacylglycerol and monoacylglycerollipase (MGL) catalyzes the hydrolysis of monoacylglycerol to glycerol. Perilipin 1A is...
Lipoprotein lipase (LPL) (EC 3.1.1.34, systematic name triacylglycerol acylhydrolase (lipoprotein-dependent)) is a member of the lipase gene family, which...
degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerollipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors...
Monoglycerides (also: acylglycerols or monoacylglycerols) are a class of glycerides which are composed of a molecule of glycerol linked to a fatty acid...
diacylglycerol, releasing a free fatty acid and monoacylglycerol: diacylglycerol + H2O ⇌ monoacylglycerol + free fatty acid DAGL has been studied in multiple...
Hashimotodani Y, Ohno-Shosaku T, Kano M (2007). "Presynaptic monoacylglycerollipase activity determines basal endocannabinoid tone and terminates retrograde...
alpha/beta-Hydrolase domain containing 6 (ABHD6), also known as monoacylglycerollipase ABHD6 or 2-arachidonoylglycerol hydrolase is an enzyme that in...
lipases, including hormone sensitive lipase, monoacylglycerollipase, adipose triglyceride lipase, and diacylglycerol lipase Cholinesterases, including acetylcholinesterase...
potent inhibitor of both fatty acid amide hydrolase (FAAH) and monoacylglycerollipase (MAGL), the primary enzymes responsible for degrading the endocannabinoids...
2-AG hydrolysis. Together, ABHD12 along with two other enzymes, monoacylglycerollipase (MAGL) and ABHD6, control 99% of 2-AG hydrolysis in the brain....
which allows the lipase to break apart the fat more effectively. The resulting monomers (2 free fatty acids and one 2-monoacylglycerol) are then moved...
cannabinoid ligand) in rat brain presumably by inhibiting the enzyme monoacylglycerollipase (MAGL), which is the primary metabolic enzyme of 2-AG. However...
JZL184 is an irreversible inhibitor for monoacylglycerollipase (MAGL), the primary enzyme responsible for degrading the endocannabinoid 2-arachidonoylglycerol...
of ATGL and HSL liberates the first two fatty acids. Cellular monoacylglycerollipase (MGL), liberates the final fatty acid. The remaining glycerol enters...
by Piomelli et al. to be a potent, noncompetitive inhibitor of monoacylglycerollipase (MGL). However, recent studies have shown that URB754 failed to...
00130. PMC 3671288. PMID 23760108. Deng H, Li W (April 2020). "Monoacylglycerollipase inhibitors: modulators for lipid metabolism in cancer malignancy...
2-AG by diacylglycerol lipase. 2-AG can also activate both cannabinoid receptors and is inactivated by monoacylglycerollipase. It is present at approximately...
of only 6300 nM, while it is a potent inhibitor of two enzymes monoacylglycerollipase (MAGL), the primary enzyme responsible for degrading the endocannabinoid...
Laws of Massachusetts, also known as Massachusetts General Laws Monoacylglycerollipase, a human protein Multiple grenade launcher, such as the Milkor...
Research in La Jolla, California. There he discovered a role for monoacylglycerollipase in generating oncogenic signaling lipids that promote cancer and...
2-Arachidonoylglycerol Production by Astrocytes, a Response Limited by MonoacylglycerolLipase". Journal of Neuroscience. 24 (3): 8068–8074. doi:10.1523/jneurosci...
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