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Dextran 70 information


Dextran 70
Clinical data
Trade namesRescueFlow, others
AHFS/Drugs.comMonograph
Routes of
administration
intravenous
ATC code
  • B05AA05 (WHO)
Legal status
Legal status
  • US: ℞-only
Identifiers
CAS Number
  • 9004-54-0
DrugBank
  • DB09255
UNII
  • 7SA290YK68
Chemical and physical data
Molar mass70000 Da

Dextran 70 is a type of fluid given by injection into a vein to expand blood volume.[1] Specifically it is used for shock such as that caused by bleeding or burns when blood transfusions are not quickly available.[2] However, it does not carry oxygen.[2]

Common side effects include vomiting, fever, and joint pains.[2] Other side effects include allergic reactions and poor blood clotting.[1] It is not recommended in people with kidney failure, significant heart failure, or a clotting disorder.[2] It is not recommended during pregnancy.[3] It works by pulling fluid from the extravascular space into the blood vessels.[2]

Dextran 70 was approved for medical use in 1947.[4] It is on the World Health Organization's List of Essential Medicines.[5] It comes in either sodium chloride solution or glucose solution.[2]

  1. ^ a b World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 248, 257–58, 279, 287. hdl:10665/44053. ISBN 9789241547659.
  2. ^ a b c d e f "Dextran 70". The American Society of Health-System Pharmacists. Archived from the original on 3 January 2017. Retrieved 8 December 2016.
  3. ^ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 686. ISBN 9780857111562.
  4. ^ BeMiller JN, Whistler RL (2012). Industrial Gums: Polysaccharides and Their Derivatives (3 ed.). Academic Press. p. 411. ISBN 9780080926544. Archived from the original on 2017-01-03.
  5. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

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Sucrose

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Streptococcus mutans bacteria convert it into a sticky, extracellular, dextran-based polysaccharide that allows them to cohere, forming plaque. Sucrose...

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Tibicos

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has been identified as the species responsible for the production of the dextran polysaccharide that forms the "grains". As with milk kefir "grains", the...

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hyperbaric oxygen, dapsone, antihistamines (e.g., cyproheptadine), antibiotics, dextran, glucocorticoids, vasodilators, heparin, nitroglycerin, electric shock...

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Leuconostoc

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species within this genus are heterofermentative and are able to produce dextran from sucrose. They are generally slime-forming. Blamed for causing the...

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Hapten

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hapten inhibitor is dextran 1, which is a small fraction (1 kilodalton) of the entire dextran complex, which is enough to bind anti-dextran antibodies, but...

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Streptococcus mutans

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a sticky, extracellular, dextran-based polysaccharide that allows them to cohere, forming plaque. S. mutans produces dextran via the enzyme dextransucrase...

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Mucus

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"Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model". PLOS ONE. 5 (8): e12238. Bibcode:2010PLoSO...512238J...

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Bradford protein assay

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"Protein quantification in the presence of poly(ethylene glycol) and dextran using the Bradford method". Analytical Biochemistry. 395 (1): 108–110....

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Psicose

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was 33 to 36 grams per day. The sweetness of allulose is estimated to be 70% of the sweetness of sucrose. It has some cooling sensation and no bitterness...

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of sugars Carob syrup – made from carob pods Caster sugar Coconut sugar – 70-79% sucrose and 3-9% glucose and fructose Confectioner's sugar (also known...

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(2000). "In vitro and in vivo evaluations of sodium lauryl sulfate and dextran sulfate as microbicides against herpes simplex and human immunodeficiency...

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few percent branching.: 58  In general, plant inulins contain between 2 and 70 fructose units: 58  or sometimes as high as 200,: 17  but molecules with less...

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range of pH from 2.6 to 7.0 and with a soluble solids content between 10 and 70%.[citation needed] The non-esterified galacturonic acid units can be either...

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Amylopectin

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amylopectin, to initiate the hydrolysis of starch. Starch is made of about 70–80% amylopectin by weight, though it varies depending on the source. For example...

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Glucose

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Comparative genomic hybridization

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which contains 50% formamide to decrease DNA melting temperature and 10% dextran sulphate to increase the effective probe concentration in a saline sodium...

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Starch

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used as a bland-tasting filler and thickener. Various glucose syrups (DE 30–70), also called corn syrups in the US, viscous solutions used as sweeteners...

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