Desonide information

Desonide
Clinical data
Trade names	Desowen
Other names	Prednacinolone; Hydroxyprednisolone acetonide; Desfluorotriamcinolone acetonide; (11β,16α)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione
AHFS/Drugs.com	Monograph
MedlinePlus	a605025
Routes of; administration	topical
ATC code	D07AB08 (WHO) S01BA11 (WHO);
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one;
CAS Number	638-94-8 ;
PubChem CID	12536;
IUPHAR/BPS	7066;
DrugBank	DB01260 ;
ChemSpider	4470603 ;
UNII	J280872D1O;
KEGG	D03696 ;
ChEBI	CHEBI:204734 ;
ChEMBL	ChEMBL1201109 ;
CompTox Dashboard (EPA)	DTXSID7046756 ;
ECHA InfoCard	100.010.320
Chemical and physical data
Formula	C24H32O6
Molar mass	416.514 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C\1\C=C/[C@]2(/C(=C/1)CC[C@H]3[C@H]4[C@](C[C@H](O)[C@H]23)([C@@]5(OC(O[C@@H]5C4)(C)C)C(=O)CO)C)C;
	InChI InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1 ; Key:WBGKWQHBNHJJPZ-LECWWXJVSA-N ;
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Desonide (INN) is a low-potency topical corticosteroid anti-inflammatory that has been available since the 1970s. It is primarily used to treat atopic dermatitis (eczema), seborrheic dermatitis, contact dermatitis and psoriasis in both adults and children. It has a fairly good safety profile^[1] and is available as a cream, ointment, lotion, and as a foam under the tradename Verdeso Foam. Other trade names for creams, lotions, and ointments include Tridesilon, DesOwen, Desonate. It is a group VI corticosteroid under US classification, the second least potent group.

^ Wong VK, Fuchs B, Lebwohl M (2004). "Overview on desonide 0.05%: a clinical safety profile". Journal of Drugs in Dermatology. 3 (4): 393–7. PMID 15303783.

[1] Wong VK, Fuchs B, Lebwohl M (2004). "Overview on desonide 0.05%: a clinical safety profile". Journal of Drugs in Dermatology. 3 (4): 393–7. PMID 15303783.

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