Methylprednisolone acetate, sold under the brand names Depo-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 acetate ester of methylprednisolone—which is used in clinical and veterinary medicine.[1][2][3][4][5][6][7] It has been formulated as an aqueous suspension for intramuscular, intra-articular, soft tissue, and intralesional injection alone and in combination with lidocaine, a local anesthetic.[1][4][5] Methylprednisolone acetate was previously suspended with polyethylene glycol but is no longer formulated with this excipient due to concerns about possible toxicity.[6][8] Depo methylprednisolone acetate is a depot injection and is absorbed slowly with a duration of weeks to months with a single intramuscular injection.[5]
^ ab"Depo-Medrol- methylprednisolone acetate injection, suspension". DailyMed. 18 January 2019. Retrieved 19 February 2020.
^Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 811–. ISBN 978-1-4757-2085-3.
^Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 675–. ISBN 978-3-88763-075-1.
^ abMuller NF, Dessing RP, eds. (19 June 1998). European Drug Index: European Drug Registrations (Fourth ed.). CRC Press. pp. 337–. ISBN 978-3-7692-2114-5.
^ abcPlumb DC (21 February 2018). Plumb's Veterinary Drug Handbook: Pocket. John Wiley & Sons. pp. 1088–1091. ISBN 978-1-119-34649-4.
^ abLennard TA, Vivian DG, Walkowski, Singla AK (11 June 2011). Pain Procedures in Clinical Practice E-Book. Elsevier Health Sciences. pp. 8–. ISBN 978-1-4377-3774-5.
^Scott DW, Miller Jr WH (1 December 2010). Equine Dermatology - E-Book. Elsevier Health Sciences. pp. 122–. ISBN 978-1-4377-0921-6.
^Canale ST, Beaty JH (29 October 2012). Campbell's Operative Orthopaedics E-Book. Elsevier Health Sciences. pp. 1906–. ISBN 978-0-323-08718-6.
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