Prednisone is a glucocorticoid medication mostly used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases.[3] It is also used to treat high blood calcium due to cancer and adrenal insufficiency along with other steroids.[3] It is taken by mouth.[3]
Common side effects may include cataracts, bone loss, easy bruising, muscle weakness, and thrush.[3] Other side effects include weight gain, swelling, high blood sugar, increased risk of infection, and psychosis.[4][3] It is generally considered safe in pregnancy and low doses appear to be safe while the user is breastfeeding.[5] After prolonged use, prednisone must be stopped gradually.[3]
Prednisone is a prodrug and must be converted to prednisolone by the liver before it becomes active.[6][7] Prednisolone then binds to glucocorticoid receptors, activating them and triggering changes in gene expression.[4]
Prednisone was patented in 1954 and approved for medical use in the United States in 1955.[3][8] It is on the World Health Organization's List of Essential Medicines.[9] It is available as a generic medication.[3] In 2021, it was the 28th most commonly prescribed medication in the United States, with more than 19million prescriptions.[10][11]
^"Product monograph brand safety updates". Health Canada. 7 July 2016. Retrieved 3 April 2024.
^Pickup ME (1979). "Clinical pharmacokinetics of prednisone and prednisolone". Clinical Pharmacokinetics. 4 (2): 111–128. doi:10.2165/00003088-197904020-00004. PMID 378499. S2CID 12218704.
^ abcdefgh"Prednisone Monograph for Professionals". Drugs.com. AHFS. Retrieved 24 December 2018.
^ abBrunton L (2017). Goodman & Gilman's the pharmacological basis of therapeutics (13 ed.). McGraw-Hill Education. pp. 739, 746, 1237. ISBN 978-1-25-958473-2.
^"Prednisone Use During Pregnancy". Drugs.com. Retrieved 24 December 2018.
^"Product Information Panafcort (prednisone) Panafcortelone (prednisolone)" (PDF). TGA eBusiness Services. St Leonards, Australia: Aspen Pharmacare Australia Pty Ltd. 11 July 2017. pp. 1–2. Retrieved 30 June 2018.
^Buttgereit F, Gibofsky A (June 2013). "Delayed-release prednisone - a new approach to an old therapy". Expert Opinion on Pharmacotherapy. 14 (8): 1097–1106. doi:10.1517/14656566.2013.782001. PMID 23594208. S2CID 22720230.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 485. ISBN 9783527607495.
^World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Prednisone - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Prednisone is a glucocorticoid medication mostly used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic...
as a skin cream, or as eye drops. It differs from the similarly named prednisone in having a hydroxyl at the 11th carbon instead of a ketone. Side effects...
potent derivative of triamcinolone, and is about eight times as potent as prednisone. Most forms of triamcinolone acetonide are prescription drugs. In 2014...
Dexamethasone and its derivatives are almost pure glucocorticoids, while prednisone and its derivatives have some mineralocorticoid action in addition to...
1016/0039-128X(92)90013-Y. PMID 1481225. S2CID 21779154. "Prednisone Half Life Is A Good Medicine". PrednisoneSideEffects.org. Archived from the original on January...
wrestler. In addition to asthma, his bones were so brittle from taking prednisone that he would often break them while performing simple wrestling maneuvers...
accurate diagnosis is the first concern. In auto-immune liver disease, prednisone and azathioprine may be used for treatment. In lymphoma the treatment...
PMID 27843811. Rado JP, Blumenfeld G, Hammer S (Nov 1959). "The effect of prednisone and 6-methylprednisolone on mercurial diuresis in patients with refractory...
where the condition causes significant health problems, steroids such as prednisone are indicated. Medications such as methotrexate, chloroquine, or azathioprine...
additional disorder, a biopsy sample may be taken from the temporal artery. Prednisone is the drug of choice for PMR, and treatment duration is frequently greater...
drugs In pharmacologic (supraphysiologic) doses, glucocorticoids, such as prednisone, dexamethasone, and hydrocortisone are used to suppress various allergic...
21-desacetyldeflazacort. Deflazacort's potency is around 70–90% that of prednisone. A 2017 review found its activity of 7.5 mg of deflazacort is approximately...
He is best known for his isolation and reproduction of the steroids prednisone and prednisolone. Arthur Nobile was born in Newark, New Jersey on May...
such as neostigmine and pyridostigmine. Immunosuppressants, such as prednisone or azathioprine, may also be used. The surgical removal of the thymus...
he fired a few rounds in his home. He said, "I was in the throes of prednisone coming out of my body [...] I shot a few rounds off and instantly was...
CD013356. doi:10.1002/14651858.CD013356.pub2. PMC 8916090. PMID 35275399. "Prednisone and other corticosteroids: Balance the risks and benefits". Mayo Clinic...
surgery, general stress Medication induced – corticosteroids (for example, prednisone, β-agonists, lithium) Cancer – either by growth factors secreted by the...
emphasize the differences between similar-looking product names such as predniSONE and predniSOLONE; and snake case, which uses underscores interspersed...
errors. For example, in tall man lettering, "prednisone" and "prednisolone" should be written "predniSONE" and "predniSOLONE", respectively. The Office...
pressure medications, including diuretics, or steroid medicines such as prednisone. NSAIDs such as naproxen may interfere with and reduce the efficacy of...
Global Information
(what is this?) (verify)