activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
cellular respiration
protein dephosphorylation
mitochondrial electron transport, cytochrome c to oxygen
apoptotic process
mitochondrial electron transport, ubiquinol to cytochrome c
cellular response to oxidative stress
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
54205
13063
Ensembl
ENSG00000172115
ENSMUSG00000063694
UniProt
P99999
P62897
RefSeq (mRNA)
NM_018947
NM_007808
RefSeq (protein)
NP_061820
NP_031834
Location (UCSC)
Chr 7: 25.12 – 25.13 Mb
Chr 6: 50.54 – 50.54 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Heme prosthetic group of cytochrome c, consisting of a rigid porphyrin ring coordinated with an iron atom.
The cytochrome complex, or cyt c, is a small hemeprotein found loosely associated with the inner membrane of the mitochondrion where it plays a critical role in cellular respiration.
It transfers electrons between Complexes III (Coenzyme Q – Cyt c reductase) and IV (Cyt c oxidase). Cytochrome c is highly water-soluble, unlike other cytochromes. It is capable of undergoing oxidation and reduction as its iron atom converts between the ferrous and ferric forms, but does not bind oxygen. It also plays a major role in cell apoptosis. In humans, cytochrome c is encoded by the CYCS gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000172115 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000063694 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: cytochrome c".
^Tafani M, Karpinich NO, Hurster KA, Pastorino JG, Schneider T, Russo MA, Farber JL (March 2002). "Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition". The Journal of Biological Chemistry. 277 (12): 10073–82. doi:10.1074/jbc.M111350200. PMID 11790791.
The cytochrome complex, or cyt c, is a small hemeprotein found loosely associated with the inner membrane of the mitochondrion where it plays a critical...
The enzyme cytochromec oxidase or Complex IV, (was EC 1.9.3.1, now reclassified as a translocase EC 7.1.1.9) is a large transmembrane protein complex...
Biochemistry and Molecular Biology (IUBMB), cytochromes a, cytochromes b, cytochromesc and cytochrome d. Cytochrome function is linked to the reversible redox...
Cytochromec oxidase I (COX1) also known as mitochondrially encoded cytochromec oxidase I (MT-CO1) is a protein that is encoded by the MT-CO1 gene in...
Cytochromec reductase may refer to: Coenzyme Q – cytochromec reductase, an enzyme NADH dehydrogenase, an enzyme This set index page lists enzyme articles...
two molecules of cytochromec, the efficiency would be halved, with only one proton transferred per cytochromec reduced. Cytochromec oxidase, also known...
Cytochromesc (cyt c, c-type cytochromes) cytochromes, or heme-containing proteins, that have heme C covalently attached to the peptide backbone via one...
the process of apoptosis. Its formation is triggered by the release of cytochromec from the mitochondria in response to an internal (intrinsic) or external...
prokaryotes, cytochrome b is a component of respiratory chain complex III (EC 1.10.2.2) — also known as the bc1 complex or ubiquinol-cytochromec reductase...
Complex III (cytochrome bc1 complex; labeled III), which passes them to cytochromec (cyt c). Cyt c passes electrons to Complex IV (cytochromec oxidase;...
fatal. Copper is required for the functioning of many enzymes, such as cytochromec oxidase, which is complex IV in the mitochondrial electron transport...
to cytochromec in the mitochondrial respiratory chain. It is formed in the cytosol and targeted to the mitochondrial intermembrane space. Cytochrome c1...
cytochromec oxidase, which is regulated by the availability of its substrate – the reduced form of cytochromec. The amount of reduced cytochromec available...
needed] Complex III (EC 1.10.2.2) (also referred to as cytochrome bc1 or the coenzyme Q : cytochromec – oxidoreductase) is a proton pump driven by electron...
the folding of some proteins, including HIV-1 reverse transcriptase; cytochromec; and nucleases. Omega loops can contribute to protein function. For example...
oxidase test is used to determine whether an organism possesses the cytochromec oxidase enzyme. The test is used as an aid for the differentiation of...
Cytochromec oxidase subunit III (COX3) is an enzyme that in humans is encoded by the MT-CO3 gene. It is one of main transmembrane subunits of cytochrome...
originally diverged. If this is correct, the cytochromec of all mammals should be equally different from the cytochromec of all birds. Since fish diverges from...
oxidized cytochromec at the Qo site. In the second step, two more electrons reduce UQ to UQH2 at the Qi site. The total reaction is: 2 cytochromec ⏟ oxidized...
reach the site of the reaction. On the other hand, for an enzyme such as cytochromec peroxidase, the compounds that donate electrons are very specific, due...
mineral because it is a key constituent of the respiratory enzyme complex cytochromec oxidase. In molluscs and crustaceans, copper is a constituent of the...
of cytochromec structure and function, with myriad c type cytochromes acting primarily as electron carriers. The redox potential for cytochromec can...
SCO2 cytochromec oxidase assembly (also known as SCO2 homolog, mitochondrial and SCO cytochrome oxidase deficient homolog 2) is a protein that in humans...
molecule of subsequent pathways that activate apoptosis. During apoptosis, cytochromec is released from mitochondria through the actions of the proteins Bax...
Cytochromec nitrite reductase (ccNiR) (EC 1.7.2.2) is a bacterial enzyme that catalyzes the six electron reduction of nitrite to ammonia; an important...
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