Cromakalim information

Cromakalim
Clinical data
ATC code	none;
Identifiers
	IUPAC name (3R,4S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile;
CAS Number	94470-67-4 ;
PubChem CID	71191;
ChemSpider	64327;
UNII	0G4X367WA3;
ChEMBL	ChEMBL11684;
CompTox Dashboard (EPA)	DTXSID301317350 ;
Chemical and physical data
Formula	C16H18N2O3
Molar mass	286.331 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C3N([C@H]1c2c(OC([C@@H]1O)(C)C)ccc(C#N)c2)CCC3;

Cromakalim (INN) is a potassium channel-opening vasodilator. The active isomer is levcromakalim. It acts on ATP-sensitive potassium channels and so causes membrane hyperpolarization. It can be used to treat hypertension as it will relax vascular smooth muscle to lower blood pressure. Hyperpolarisation of smooth muscle cell membranes pulls their membrane potential away from the threshold, so making it more difficult to excite them and thereby cause relaxation.

Cromakalim information

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Clinical data


ATC code	none
Identifiers
IUPAC name (3R,4S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
CAS Number	94470-67-4^Y
PubChem CID	71191
ChemSpider	64327
UNII	0G4X367WA3
ChEMBL	ChEMBL11684
CompTox Dashboard (EPA)	DTXSID301317350
Chemical and physical data
Formula	C₁₆H₁₈N₂O₃
Molar mass	286.331 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C3N([C@H]1c2c(OC([C@@H]1O)(C)C)ccc(C#N)c2)CCC3