Cooperative binding occurs in molecular binding systems containing more than one type, or species, of molecule and in which one of the partners is not mono-valent and can bind more than one molecule of the other species. In general, molecular binding is an interaction between molecules that results in a stable physical association between those molecules.
Cooperative binding occurs in a molecular binding system where two or more ligand molecules can bind to a receptor molecule. Binding can be considered "cooperative" if the actual binding of the first molecule of the ligand to the receptor changes the binding affinity of the second ligand molecule. The binding of ligand molecules to the different sites on the receptor molecule do not constitute mutually independent events. Cooperativity can be positive or negative, meaning that it becomes more or less likely that successive ligand molecules will bind to the receptor molecule.
Cooperative binding is observed in many biopolymers, including proteins and nucleic acids. Cooperative binding has been shown to be the mechanism underlying a large range of biochemical and physiological processes.
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Cooperativebinding occurs in molecular binding systems containing more than one type, or species, of molecule and in which one of the partners is not...
lack cooperativebinding to oxygen, making it roughly 1/4 as efficient as hemoglobin. In some brachiopods though, hemerythrin shows cooperativebinding of...
that have multiple binding sites where the affinity of the binding sites for a ligand is apparently increased, positive cooperativity, or decreased, negative...
influencing the shape of the binding sites for the next ones, in a way favorable for binding. This positive cooperativebinding is achieved through steric...
cases of cooperativebinding hemocyanin was arranged in protein sub-complexes of 6 subunits (hexamer) each with one oxygen binding site; binding of oxygen...
allosteric site of a multimeric enzyme often induces positive cooperativity, that is the binding of one substrate induces a favorable conformation change and...
have multiple coupled domains/subunits and show cooperativebinding. Generally speaking, such cooperativity results in allosteric enzymes displaying a sigmoidal...
its affinity for the ligand at neighboring binding sites. It gives one explanation for cooperativebinding. This model for allosteric regulation of enzymes...
hemoglobin, myoglobin has a higher affinity for oxygen and does not have cooperativebinding with oxygen like hemoglobin does. Myoglobin consists of non-polar...
a cooperative game (or coalitional game) is a game with groups of players who form binding “coalitions” with external enforcement of cooperative behavior...
in 1904 by the Danish physiologist Christian Bohr. Hemoglobin's oxygen binding affinity (see oxygen–haemoglobin dissociation curve) is inversely related...
hydrogen ions and carbon dioxide heterotopically decrease hemoglobin's oxygen-binding affinity. This regulation increases the efficiency of oxygen release by...
have interpreted HP1 binding in terms of nearest-neighbor cooperativebinding. However, the analysis of available data on HP1 binding to nucleosomal arrays...
Calcium binding by calmodulin exhibits considerable cooperativity, making calmodulin an unusual example of a monomeric (single-chain) cooperativebinding protein...
of one site. Cooperativity between single binding contributions in such supramolecular systems is positive if occupation of one binding site enhances...
Somatomammotropin Enhancer Function Is Mediated by CooperativeBinding of TEF-1 and CSEF-1 to Multiple, Low-Affinity Binding Sites". Archived from the original on...
is the single-stranded DNA binding protein that presumably coats the T- strand in the host cytoplasm by cooperativebinding. It is then directed into the...
often indicates cooperativebinding of substrate to the active site. This means that the binding of one substrate molecule affects the binding of subsequent...
order OR1 > OR2 > OR3. Binding of a cI dimer to OR1 enhances binding of a second cI dimer to OR2, an effect called cooperativity. Thus, OR1 and OR2 are...
its ligand. Therefore, hormone binding to its receptor is a complex process that can be mediated by cooperativebinding, reversible and irreversible interactions...
suggesting that the IR and its respective ligand share a relationship of cooperativebinding. Furthermore, the observation that the rate of IR-ligand dissociation...
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