A hormone receptor is a receptor molecule that binds to a specific hormone. Hormone receptors are a wide family of proteins made up of receptors for thyroid and steroid hormones, retinoids and Vitamin D, and a variety of other receptors for various ligands, such as fatty acids and prostaglandins.[1] Hormone receptors are of mainly two classes. Receptors for peptide hormones tend to be cell surface receptors built into the plasma membrane of cells and are thus referred to as trans membrane receptors. An example of this is Actrapid.[2] Receptors for steroid hormones are usually found within the protoplasm and are referred to as intracellular or nuclear receptors, such as testosterone.[3] Upon hormone binding, the receptor can initiate multiple signaling pathways, which ultimately leads to changes in the behavior of the target cells.
Hormonal therapy and hormone receptors play a very large part in breast cancer treatment (therapy is not limited to only breast cancer). By influencing the hormones, the cells' growth can be changed along with its function. These hormones can cause cancer to not survive in the human body.[4]
^Gammeltoft, S. (1984-10-01). "Insulin receptors: binding kinetics and structure-function relationship of insulin". Physiological Reviews. 64 (4): 1321–1378. doi:10.1152/physrev.1984.64.4.1321. ISSN 0031-9333. PMID 6387730.
^McEwen, B. S.; Kloet, E. R. De; Rostene, W. (1986-10-01). "Adrenal steroid receptors and actions in the nervous system". Physiological Reviews. 66 (4): 1121–1188. doi:10.1152/physrev.1986.66.4.1121. ISSN 0031-9333. PMID 3532143.
^"Understanding Hormone Receptors and What They Do". Breastcancer.org. Retrieved 2017-04-06.
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