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complement component 4A (Rodgers blood group)
Identifiers
Symbol
C4A
NCBI gene
720
HGNC
1323
OMIM
120810
RefSeq
NM_007293
UniProt
P0C0L4
Other data
Locus
Chr. 6 p21.3
Search for
Structures
Swiss-model
Domains
InterPro
complement component 4B (Chido blood group)
Identifiers
Symbol
C4B
NCBI gene
721
HGNC
1324
OMIM
120820
RefSeq
NM_000592
UniProt
P0C0L5
Other data
Locus
Chr. 6 p21.3
Search for
Structures
Swiss-model
Domains
InterPro
Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system. It serves a number of critical functions in immunity, tolerance, and autoimmunity with the other numerous components. Furthermore, it is a crucial factor in connecting the recognition pathways of the overall system instigated by antibody-antigen (Ab-Ag) complexes to the other effector proteins of the innate immune response. For example, the severity of a dysfunctional complement system can lead to fatal diseases and infections. Complex variations of it can also lead to schizophrenia.[1] The C4 protein was thought to derive from a simple two-locus allelic model, which however has been replaced by a much more sophisticated multimodular RCCX gene complex model which contain long and short forms of the C4A or C4B genes usually in tandem RCCX cassettes with copy number variation, that somewhat parallels variation in the levels of their respective proteins within a population along with CYP21 in some cases depending on the number of cassettes and whether it contains the functional gene instead of pseudogenes or fragments.[2] Originally defined in the context of the Chido/Rodgers blood group system, the C4A-C4B genetic model is under investigation for its possible role in schizophrenia risk and development.
^Cite error: The named reference Sekar was invoked but never defined (see the help page).
^Yang Y, Chung EK, Zhou B, Blanchong CA, Yu CY, Füst G, Kovács M, Vatay A, Szalai C, Karádi I, Varga L (September 2003). "Diversity in intrinsic strengths of the human complement system: serum C4 protein concentrations correlate with C4 gene size and polygenic variations, hemolytic activities, and body mass index". Journal of Immunology. 171 (5): 2734–45. doi:10.4049/jimmunol.171.5.2734. PMID 12928427.
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Complementcomponent 4B (Chido blood group) is a kind of the Complementcomponent4 protein that in humans is encoded by the C4B gene. This gene encodes...
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component of fresh serum. Ehrlich, therefore, named this heat-labile component "complement", because it is something in the blood that "complements"...
Complement C4-A is a kind of the Complementcomponent4 protein that in humans is encoded by the C4A gene. This gene encodes the acidic form of complement...
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in particular complementcomponent4. The vascular deposition of these types of cryoglobulin-containing immune complexes and complement can cause a clinical...
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column C04, oral cancer ICD-10 code Complement component4, a protein involved in the intricate complement system, encoded by C4A or C4B gene in humans...
functioning of the immune system. Other blood proteins act as enzymes, complementcomponents, protease inhibitors or kinin precursors. Contrary to popular belief...
classical complement pathway is one of three pathways which activate the complement system, which is part of the immune system. The classical complement pathway...
pruning. Genes in the ComplementComponent4 (C4) locus of the major histocompatibility complex (MHC), which encode for complement factors, have also been...
cells, leading to cell lysis and death. The MAC is composed of the complementcomponents C5b, C6, C7, C8 and several C9 molecules. A number of proteins participate...
visual cortex critical period. More recently, the expression of the complementcomponent4 gene has been found to significantly contribute to abnormally high...
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Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway...
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