positive regulation of G protein-coupled receptor signaling pathway
positive regulation of apoptotic cell clearance
immune response
complement activation, classical pathway
regulation of immune response
positive regulation of activation of membrane attack complex
positive regulation of vascular endothelial growth factor production
inflammatory response
positive regulation of glucose transmembrane transport
regulation of complement activation
signal transduction
negative regulation of endopeptidase activity
regulation of triglyceride biosynthetic process
proteolysis
innate immune response
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
718
12266
Ensembl
ENSG00000125730
ENSMUSG00000024164
UniProt
P01024
P01027
RefSeq (mRNA)
NM_000064
NM_009778
RefSeq (protein)
NP_000055
NP_033908
Location (UCSC)
Chr 19: 6.68 – 6.73 Mb
Chr 17: 57.51 – 57.54 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a central role in the complement system of vertebrate animals and contributes to innate immunity. In humans it is encoded on chromosome 19 by a gene called C3.[5][6]
Deficiencies and defects of C3 result in the affected person being immunocompromised and particularly vulnerable to bacterial infections.
^ abcGRCh38: Ensembl release 89: ENSG00000125730 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024164 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^de Bruijn MH, Fey GH (Feb 1985). "Human complement component C3: cDNA coding sequence and derived primary structure". Proceedings of the National Academy of Sciences of the United States of America. 82 (3): 708–12. Bibcode:1985PNAS...82..708D. doi:10.1073/pnas.82.3.708. PMC 397115. PMID 2579379.
^"Entrez Gene: C3 complement component 3".
and 28 Related for: Complement component 3 information
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express complement receptors on their surface. All four complement receptors can bind to fragments of complementcomponent3 or complementcomponent 4 coated...
Complementcomponent 6 is a protein that in humans is encoded by the C6 gene. Complementcomponent 6 is a protein involved in the complement system. It...
C3b is the larger of two elements formed by the cleavage of complementcomponent3, and is considered an important part of the innate immune system. C3b...
functioning of the immune system. Other blood proteins act as enzymes, complementcomponents, protease inhibitors or kinin precursors. Contrary to popular belief...
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the component of IgA can associate with the mucus layer that sits atop epithelial cells. Since sIgA is a poor opsonin and activator of complement, simply...
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interact with complementcomponent3, amongst other complement proteins and factors, leading to regulation of the alternative pathway of complement in particular...
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cells, leading to cell lysis and death. The MAC is composed of the complementcomponents C5b, C6, C7, C8 and several C9 molecules. A number of proteins participate...
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