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Complement 4 deficiency information


Complement 4 deficiency
SpecialtyImmunology
Complement tests
C4 (C) FB (A) C3 CH50 Conditions
· PSG, C3 NeF AA
· · HAE, C4D
· · · TCPD
·/↓ SLE
inflammation

Complement 4 deficiency is a genetic condition affecting complement component 4.[1]

It can present with lupus-like symptoms.[2]

  1. ^ Parija (2009). Textbook of Microbiology & Immunology. Elsevier India. pp. 125–. ISBN 978-81-312-2163-1. Retrieved 13 November 2010.
  2. ^ David L. Rimoin; J. Michael Connor; Reed E. Pyeritz; Bruce R. Korf (15 December 2006). Principles and Practice of Medical Genetics: Continually Updated Online Reference. Elsevier Health Sciences. pp. 1860–. ISBN 978-0-443-06870-6. Retrieved 13 November 2010.

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Complement 4 deficiency

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Complement 4 deficiency is a genetic condition affecting complement component 4. It can present with lupus-like symptoms. Parija (2009). Textbook of Microbiology...

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Complement deficiency

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Complement component 3

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of the complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible...

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Complement 2 deficiency

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Complement 2 deficiency is a type of complement deficiency caused by any one of several different alterations in the structure of complement component...

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Complement component 2

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the complement system, acting as a multi-domain serine protease. Deficiency of C2 has been associated with certain autoimmune diseases. The Complement system...

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Classical complement pathway

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cells, killing them. Lack of regulation of the classical complement pathway through the deficiency in C1-inhibitor results in episodic angioedema. C1-inhibitor...

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Complement component 4

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Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system...

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Complement component 5

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the complement membrane attack complex. Deficiency is thought to cause Leiner's disease. Complement component 5 is the fifth component of complement, which...

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Total complement activity

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C3/C4 values but a decreased CH50, that can indicate a terminal complement pathway deficiency while if one has low C3 and CH50 values that can indicate an...

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Complement system

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"Infections of people with complement deficiencies and patients who have undergone splenectomy". Clinical Microbiology Reviews. 23 (4): 740–80. doi:10.1128/CMR...

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Acquired C1 esterase inhibitor deficiency

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of the complement cascade, such that complement proteins remain in check and do not lead to unnecessary activity. When there is a deficiency of C1-INH...

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Angioedema

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bradykinin formation is caused by continuous activation of the complement system due to a deficiency in one of its prime inhibitors, C1-esterase (aka: C1-inhibitor...

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Properdin deficiency

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Properdin deficiency is a rare X-linked disease in which properdin, an important complement factor responsible for the stabilization of the alternative...

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Lectin pathway

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pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, in that, after activation, it proceeds...

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Complement receptor

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Schwartz RA, Thomas I. "Complement Receptor Deficiency: eMedicine Dermatology". Medscape. Retrieved 7 December 2010. Complement+receptors at the U.S. National...

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Complement membrane attack complex

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Terminal complement pathway deficiency Paroxysmal nocturnal haemoglobinuria Perforin Pore-forming toxin Xie CB, Jane-Wit D, Pober JS (2020). "Complement Membrane...

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MBL deficiency

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MBL deficiency or mannose-binding lectin deficiency is an illness that has an impact on immunity. Low levels of mannose-binding lectin, an immune system...

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Hereditary angioedema

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cases with C1-inhibitor deficiency. C1-inhibitor deficiency is caused by mutations of the SERPING1 gene, the gene encoding complement C1-inhibitor. More than...

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Factor D

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Factor D (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) is a protein...

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Homocystinuria

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inherited disorder of the metabolism of the amino acid methionine due to a deficiency of cystathionine beta synthase or methionine synthase. It is an inherited...

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CARD11 deficiency MST1 deficiency TCRα deficiency LCK deficiency IL-21 deficiency IL-21R deficiency UNC119 deficiency NIK deficiency OX40 deficiency IKBKB...

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Complement factor I

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"The molecular basis of hereditary complement factor I deficiency". The Journal of Clinical Investigation. 97 (4): 925–33. doi:10.1172/JCI118515. PMC 507137...

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Paroxysmal nocturnal hemoglobinuria

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blood cells by the complement system, a part of the body's innate immune system. This destructive process occurs due to deficiency of the red blood cell...

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Complement component 1s

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Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system...

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Color blindness

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Color blindness or color vision deficiency (CVD) is the decreased ability to see color or differences in color. The severity of color blindness ranges...

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Vitamin A deficiency

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Vitamin A deficiency (VAD) or hypovitaminosis A is a lack of vitamin A in blood and tissues. It is common in poorer countries, especially among children...

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Complement component 1r

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Complement C1r subcomponent (EC 3.4.21.41, activated complement C1r, C overbar 1r esterase, C1r) is a protein involved in the complement system of the...

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Outline of immunology

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Immunodeficiency Primary immunodeficiency Acquired immunodeficiency Complement deficiency Sepsis Inflammatory bowel disease (IBD) Cytokine storm Immunoproliferative...

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